Collection of genetic data at scale for a nationally representative population: the UK Millennium Cohort Study.

Millennium Cohort Study ethnic diversity genetic data longitudinal nationally representative population

Journal

Longitudinal and life course studies : international journal
ISSN: 1757-9597
Titre abrégé: Longit Life Course Stud
Pays: England
ID NLM: 101513496

Informations de publication

Date de publication:
01 07 2021
Historique:
entrez: 3 8 2022
pubmed: 4 8 2022
medline: 6 8 2022
Statut: epublish

Résumé

A DNA bank has been created from the Millennium Cohort Study (MCS) saliva samples. A total of 23,336 samples are available, from 9,259 cohort members (4,630 males and 4,629 females), 8,898 mothers and 5,179 fathers. There are 4,533 mother, child, father 'triads'. This paper describes the collection of the saliva samples from cohort members and their biological parents in the MCS. It analyses response rates and predictors of response, and details the DNA extraction, genotyping and imputation procedures performed on the data.

Identifiants

pubmed: 35920643
doi: 10.1332/175795921X16223668101602
doi:

Substances chimiques

DNA 9007-49-2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

169-187

Subventions

Organisme : Wellcome Trust
ID : 208806/Z/17/Z
Pays : United Kingdom

Auteurs

Emla Fitzsimons (E)

University College London, UK.
Institute for Fiscal Studies, London,UK.

Vanessa Moulton (V)

University College London, UK.

David A Hughes (DA)

University of Bristol, UK.

Sam Neaves (S)

University of Bristol, UK.

Karen Ho (K)

University of Bristol, UK.

Gibran Hemani (G)

University of Bristol, UK.

Nicholas Timpson (N)

University of Bristol, UK.

Lisa Calderwood (L)

University College London, UK.

Emily Gilbert (E)

University College London, UK.

Susan Ring (S)

University of Bristol, UK.

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Classifications MeSH