Transcriptional variability accelerates preleukemia by cell diversification and perturbation of protein synthesis.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
05 08 2022
05 08 2022
Historique:
entrez:
3
8
2022
pubmed:
4
8
2022
medline:
6
8
2022
Statut:
ppublish
Résumé
Transcriptional variability facilitates stochastic cell diversification and can in turn underpin adaptation to stress or injury. We hypothesize that it may analogously facilitate progression of premalignancy to cancer. To investigate this, we initiated preleukemia in mouse cells with enhanced transcriptional variability due to conditional disruption of the histone lysine acetyltransferase gene
Identifiants
pubmed: 35921412
doi: 10.1126/sciadv.abn4886
pmc: PMC9348803
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabn4886Subventions
Organisme : Medical Research Council
ID : MC_PC_17230
Pays : United Kingdom
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