Moderating Role of Cognitive Reserve Markers Between Childhood Cognition and Cognitive Aging: Evidence From the 1946 British Birth Cohort.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
20 Sep 2022
20 Sep 2022
Historique:
received:
08
12
2021
accepted:
19
05
2022
pubmed:
4
8
2022
medline:
14
10
2022
entrez:
3
8
2022
Statut:
ppublish
Résumé
As the population ages, differences in cognitive abilities become more evident. We investigated key genetic and life course influences on cognitive state at age 69 years, building on previous work using the longitudinal Medical Research Council National Survey of Health and Development (the British 1946 birth cohort). Multivariable regressions investigated the association between 4 factors: (1) childhood cognition at age 8 years; (2) a Cognitive Reserve Index (CRI) composed of 3 markers: (i) educational attainment by age 26 years, (ii) engagement in leisure activities at age 43 years, and (iii) occupation up to age 53 years; (3) reading ability assessed by the National Adult Reading Test (NART) at age 53 years; and (4) The analytical sample comprised 1,184 participants. Higher scores in childhood cognition, CRI, and NART were associated with higher scores in the ACE-III. We found that the CRI and NART modified the association between childhood cognition and the ACE-III: for 30 additional points in the CRI or 20 additional points in the NART, the simple slope of childhood cognition decreased by approximately 0.10 points (CRI = 70: marginal effects (MEs) 0.22, 95% CI 0.12-0.32, The CRI and NART are independent measures of cognitive reserve because both modify the association between childhood cognition and cognitive state.
Sections du résumé
BACKGROUND AND OBJECTIVES
As the population ages, differences in cognitive abilities become more evident. We investigated key genetic and life course influences on cognitive state at age 69 years, building on previous work using the longitudinal Medical Research Council National Survey of Health and Development (the British 1946 birth cohort).
METHODS
Multivariable regressions investigated the association between 4 factors: (1) childhood cognition at age 8 years; (2) a Cognitive Reserve Index (CRI) composed of 3 markers: (i) educational attainment by age 26 years, (ii) engagement in leisure activities at age 43 years, and (iii) occupation up to age 53 years; (3) reading ability assessed by the National Adult Reading Test (NART) at age 53 years; and (4)
RESULTS
The analytical sample comprised 1,184 participants. Higher scores in childhood cognition, CRI, and NART were associated with higher scores in the ACE-III. We found that the CRI and NART modified the association between childhood cognition and the ACE-III: for 30 additional points in the CRI or 20 additional points in the NART, the simple slope of childhood cognition decreased by approximately 0.10 points (CRI = 70: marginal effects (MEs) 0.22, 95% CI 0.12-0.32,
DISCUSSION
The CRI and NART are independent measures of cognitive reserve because both modify the association between childhood cognition and cognitive state.
Identifiants
pubmed: 35922143
pii: WNL.0000000000200928
doi: 10.1212/WNL.0000000000200928
pmc: PMC9576292
doi:
Substances chimiques
Apolipoproteins E
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1239-e1250Subventions
Organisme : Medical Research Council
ID : MC_UU_00019/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/3
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00019/4
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG017644
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 American Academy of Neurology.
Références
Dement Geriatr Cogn Disord. 2013;36(3-4):242-50
pubmed: 23949210
Annu Rev Psychol. 2012;63:201-26
pubmed: 21740223
Aging Clin Exp Res. 2012 Jun;24(3):218-26
pubmed: 21691143
BMJ Open. 2019 Apr 24;9(4):e024404
pubmed: 31023749
Am J Psychiatry. 1997 Feb;154(2):165-72
pubmed: 9016263
Nature. 2002 Aug 29;418(6901):932
pubmed: 12198535
Scand J Med Sci Sports. 2020 May;30(5):816-827
pubmed: 32020713
Transl Psychiatry. 2018 Jan 10;8(1):18
pubmed: 29317609
Aging Ment Health. 2018 Aug;22(8):915-926
pubmed: 28703027
Ann Intern Med. 2010 Aug 3;153(3):182-93
pubmed: 20547887
J Am Geriatr Soc. 2011 Aug;59(8):1403-11
pubmed: 21797830
Dement Geriatr Cogn Disord. 2017;44(5-6):328-342
pubmed: 29414814
Neuron. 2008 Jun 12;58(5):681-93
pubmed: 18549781
Alzheimers Dement. 2020 Sep;16(9):1305-1311
pubmed: 30222945
Behav Res Methods. 2007 Nov;39(4):709-22
pubmed: 18183883
Int J Epidemiol. 2016 Aug;45(4):1207-1215
pubmed: 26968481
Arch Clin Neuropsychol. 2020 Aug 28;35(6):660-670
pubmed: 32129455
Brain. 2010 Feb;133(Pt 2):362-74
pubmed: 20008455
Lancet Neurol. 2006 Jan;5(1):87-96
pubmed: 16361026
Eur J Epidemiol. 2016 Nov;31(11):1135-1147
pubmed: 27995394
Br J Psychiatry. 2021 May;218(5):243-251
pubmed: 32223764
Neuropsychology. 2020 Jan;34(1):107-115
pubmed: 31448942
Neurobiol Aging. 2011 Jan;32(1):63-74
pubmed: 19285755
Ann Neurol. 2010 Mar;67(3):353-64
pubmed: 20373347
Soc Sci Med. 2003 Feb;56(4):785-92
pubmed: 12560011
J Clin Exp Neuropsychol. 2003 Aug;25(5):614-24
pubmed: 12815499
Ann Neurol. 2019 Jul;86(1):68-78
pubmed: 31066941
J Clin Epidemiol. 2018 Jun;98:146-151
pubmed: 29258908
J Gerontol B Psychol Sci Soc Sci. 2011 Jul;66 Suppl 1:i26-35
pubmed: 21398418
Am J Geriatr Psychiatry. 2015 Sep;23(9):885-96
pubmed: 25746486
Ann Neurol. 2005 Oct;58(4):617-22
pubmed: 16178025
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2016;23(1):40-60
pubmed: 25929288
Front Psychol. 2015 May 07;6:608
pubmed: 25999909
Brain. 2011 May;134(Pt 5):1479-92
pubmed: 21478184
Alzheimers Res Ther. 2021 Jul 12;13(1):128
pubmed: 34253231
Lancet Neurol. 2004 Jun;3(6):343-53
pubmed: 15157849
Am J Epidemiol. 2011 May 1;173(9):1004-12
pubmed: 21378129
J Alzheimers Dis. 2012;28(1):223-30
pubmed: 21971400
Brain Imaging Behav. 2017 Apr;11(2):357-367
pubmed: 27544202
Neurobiol Aging. 2019 Dec;84:239.e1-239.e8
pubmed: 31126628
PLoS Med. 2017 Mar 14;14(3):e1002251
pubmed: 28291786
Psychol Med. 1979 Feb;9(1):139-45
pubmed: 424481
Front Psychiatry. 2020 Jul 16;11:658
pubmed: 32765312