In mouse chronic pancreatitis CD25
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
03 08 2022
03 08 2022
Historique:
received:
28
06
2021
accepted:
20
07
2022
entrez:
3
8
2022
pubmed:
4
8
2022
medline:
6
8
2022
Statut:
epublish
Résumé
Chronic pancreatitis (CP) is characterized by chronic inflammation and the progressive fibrotic replacement of exocrine and endocrine pancreatic tissue. We identify Treg cells as central regulators of the fibroinflammatory reaction by a selective depletion of FOXP3-positive cells in a transgenic mouse model (DEREG-mice) of experimental CP. In Treg-depleted DEREG-mice, the induction of CP results in a significantly increased stroma deposition, the development of exocrine insufficiency and significant weight loss starting from day 14 after disease onset. In CP, FOXP3
Identifiants
pubmed: 35922425
doi: 10.1038/s41467-022-32195-2
pii: 10.1038/s41467-022-32195-2
pmc: PMC9349313
doi:
Substances chimiques
Forkhead Transcription Factors
0
Foxp3 protein, mouse
0
Il2ra protein, mouse
0
Interleukin-2 Receptor alpha Subunit
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4502Informations de copyright
© 2022. The Author(s).
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