Oral melanoma: a multicenter study of 69 patients from Japan.
Malignant melanoma
Mucosa
Oral cavity
Prognosis
Radical therapy
Journal
Clinical oral investigations
ISSN: 1436-3771
Titre abrégé: Clin Oral Investig
Pays: Germany
ID NLM: 9707115
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
19
01
2022
accepted:
27
05
2022
pubmed:
4
8
2022
medline:
5
10
2022
entrez:
3
8
2022
Statut:
ppublish
Résumé
The purpose of this multicenter retrospective study was to investigate the demographic characteristics and treatment outcomes of patients with mucosal malignant melanoma (MM) of the oral cavity. This was a multicenter study involving 8 Japanese universities. The medical records of 69 patients who were diagnosed with primary oral MM between January 2000 and December 2020 were retrospectively analyzed. Overall survival (OS) and prognostic factors for OS were analyzed statistically. There were 40 (58.0%) males and 29 (42.0%) females, and their mean (range) age was 69.8 ± 14.6 (22-96) years old. The most common primary site was the palate (30 patients, 43.5%). Stage IVA was the most common disease stage (36 patients, 52.2%). Radical therapy was performed in 55 patients (79.7%). The 2-year and 5-year OS rates of the 69 patients were 64.6% and 42.5%, respectively. The 2-year and 5-year OS rates of the stage III patients were 85.9% and 72.5%, respectively, and those of the stage IVA patients were 56.3% and 26.0%, respectively. The 1-year OS rate of the stage IVB/IVC patients was 26.7%. The 2-year and 5-year OS rates of the radical therapy group were 74.1% and 50.5%, respectively, whereas the 2-year OS rate of the non-radical therapy group was 26.0%. An advanced T classification was the only identified prognostic factor for OS (hazard ratio: 6.312, 95% confidence interval: 1.133-38.522, p < 0.05). Early detection and radical treatment are essential for improving the prognosis of oral MM patients. Early detection and adequate radical therapy leads to the better prognosis of oral MM patients.
Identifiants
pubmed: 35922680
doi: 10.1007/s00784-022-04568-w
pii: 10.1007/s00784-022-04568-w
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Pagination
6187-6193Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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