Comparison of Composite Lipid Indices in Patients with Obstructive Sleep Apnoea.
cardiovascular risk
cholesterol
lipid indices
obstructive sleep apnea
triglyceride
Journal
Nature and science of sleep
ISSN: 1179-1608
Titre abrégé: Nat Sci Sleep
Pays: New Zealand
ID NLM: 101537767
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
02
2022
accepted:
21
06
2022
entrez:
4
8
2022
pubmed:
5
8
2022
medline:
5
8
2022
Statut:
epublish
Résumé
Obstructive sleep apnoea (OSA) is a recognised risk factor for cardiovascular disease. However, it is difficult to evaluate the risk of cardiovascular disease in patients with OSA due to multiple shared risk factors. Composite lipid indices, such as atherogenic index of plasma (AIP), visceral adiposity index (VAI) and lipid accumulation product (LAP) have been shown to predict cardiovascular disease better than their individual lipid components. This study aimed to evaluate these indices in patients with OSA. Six hundred sixty-seven (667) patients with OSA and 139 non-OSA control volunteers participated in the study. Fasting serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C) levels were measured, and AIP, LAP and VAI were calculated following cardiorespiratory polygraphy. The relationship between lipid parameters, OSA and its comorbidities was evaluated using receiver operating curve (ROC) analysis. We found a significant difference in all lipid parameters between OSA patients and controls. Comparing ROCs, LAP was significantly more strongly associated with OSA compared to all the other parameters. The optimal cut-off value for LAP to detect OSA was 76.4, with a sensitivity of 63% and a specificity of 76%. In addition, LAP was the best parameter to predict hypertension and diabetes in patients with OSA, and it was predictive for ischaemic heart disease together with HDL-C. Our results support the use of LAP in clinical practice when evaluating cardiovascular risk in patients with OSA. However, the optimal cut-off value should be determined in large-scale follow-up studies.
Identifiants
pubmed: 35923809
doi: 10.2147/NSS.S361318
pii: 361318
pmc: PMC9342428
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1333-1340Informations de copyright
© 2022 Bikov et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
Références
Diabetes Care. 2010 Apr;33(4):920-2
pubmed: 20067971
BMC Cardiovasc Disord. 2005 Sep 08;5:26
pubmed: 16150143
Am J Physiol Endocrinol Metab. 2012 Aug 1;303(3):E377-88
pubmed: 22621867
Am J Epidemiol. 2013 May 1;177(9):1006-14
pubmed: 23589584
Sleep Breath. 2020 Dec;24(4):1507-1513
pubmed: 31981042
Nutr Metab (Lond). 2019 Oct 21;16:72
pubmed: 31641369
J Clin Med. 2021 Jan 22;10(3):
pubmed: 33499142
Environ Health Prev Med. 2016 Sep;21(5):321-326
pubmed: 27095251
J Sleep Res. 2020 Aug;29(4):e12979
pubmed: 31908118
Medicine (Baltimore). 2017 Sep;96(37):e8058
pubmed: 28906400
J Appl Physiol (1985). 2005 Nov;99(5):1643-8
pubmed: 16037401
Lancet. 2005 Mar 19-25;365(9464):1046-53
pubmed: 15781100
Clin Biochem. 2001 Oct;34(7):583-8
pubmed: 11738396
BMC Pulm Med. 2016 Mar 01;16:37
pubmed: 26931776
J Sleep Res. 2014 Feb;23(1):13-21
pubmed: 24118617
Obes Surg. 2019 Aug;29(8):2535-2547
pubmed: 31111342
Mayo Clin Proc. 2017 Apr;92(4):680-681
pubmed: 28385200
J Intern Med. 2003 Jul;254(1):32-44
pubmed: 12823641
BMC Endocr Disord. 2020 Dec 9;20(1):179
pubmed: 33298050
Healthcare (Basel). 2021 Oct 27;9(11):
pubmed: 34828496
J Clin Sleep Med. 2017 Mar 15;13(3):479-504
pubmed: 28162150
Sleep Breath. 2020 Dec;24(4):1373-1382
pubmed: 31832983
Sleep. 2019 Mar 1;42(3):
pubmed: 30476296
J Clin Med. 2021 Apr 03;10(7):
pubmed: 33916750
Obes Surg. 2021 May;31(5):2219-2230
pubmed: 33569729
Sleep Breath. 2015 May;19(2):593-8
pubmed: 25204854
J Transl Med. 2021 Jun 22;19(1):268
pubmed: 34158069
Metabolism. 2010 Feb;59(2):299-304
pubmed: 19796777
Appetite. 2014 Jul;78:185-92
pubmed: 24699392
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Jan;1867(1):159063
pubmed: 34637926
Obesity (Silver Spring). 2010 Sep;18(9):1836-44
pubmed: 20035284
Biometrics. 1988 Sep;44(3):837-45
pubmed: 3203132
Thorax. 2016 Apr;71(4):347-55
pubmed: 26883674
Eur Respir J. 2011 Jun;37(6):1418-23
pubmed: 21177837