Complementarity of two approaches based on the use of high-resolution mass spectrometry for the determination of multi-class antibiotics in water. Photodegradation studies and non-target screenings.
Antibiotics
Non-target analysis
Photodegradation
Photoproducts
Solid-phase extraction
UHPLC-QToF-HRMS
Journal
Environmental science and pollution research international
ISSN: 1614-7499
Titre abrégé: Environ Sci Pollut Res Int
Pays: Germany
ID NLM: 9441769
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
10
03
2022
accepted:
17
07
2022
pubmed:
5
8
2022
medline:
7
1
2023
entrez:
4
8
2022
Statut:
ppublish
Résumé
The development of analytical methodologies to monitor different antibiotic families in water and the implementation of alternatives for their efficient elimination are a great challenge. The aim of this research was to develop a method based on solid-phase extraction followed by ultra-high performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry to analyse multi-class antibiotics, including macrolides, cephalosporins, fluoroquinolones, sulfonamides and diaminopyrimidines, in waters. Several parameters affecting the extraction such as the sample pH, type of sorbent and cartridge, elution volume and breakthrough volume were optimized. The method was validated in real samples, and matrix effect was assessed, demonstrating that the use of isotopically labelled surrogate compounds was mandatory to avoid standard addition calibration for each individual samples. Urban and hospital wastewater samples, as well as natural waters, were analysed, confirming the presence of 12 of the 14 target compounds at concentrations up to 3.5 µg L
Identifiants
pubmed: 35925464
doi: 10.1007/s11356-022-22130-9
pii: 10.1007/s11356-022-22130-9
pmc: PMC9813094
doi:
Substances chimiques
Water
059QF0KO0R
Anti-Bacterial Agents
0
Water Pollutants, Chemical
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1871-1888Subventions
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : EQC2018-005011-P
Organisme : Ministerio de Ciencia, Innovación y Universidades
ID : RED2018-102522-T
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : IGDC-1E-2026
Organisme : Xunta de Galicia
ID : IN607B 2019/13
Organisme : Xunta de Galicia
ID : ED431 2020/06
Informations de copyright
© 2022. The Author(s).
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