Bone Marrow Relative Biological Effectiveness for a

Animals Mice Relative Biological Effectiveness Bone Marrow Lead Radiometry Antibodies, Monoclonal / therapeutic use

Journal

International journal of radiation oncology, biology, physics
ISSN: 1879-355X
Titre abrégé: Int J Radiat Oncol Biol Phys
Pays: United States
ID NLM: 7603616

Informations de publication

Date de publication:
01 02 2023
Historique:
received: 08 03 2022
revised: 25 07 2022
accepted: 28 07 2022
pubmed: 5 8 2022
medline: 11 1 2023
entrez: 4 8 2022
Statut: ppublish

Résumé

We have determined the in vivo relative biological effectiveness (RBE) of an alpha-particle-emitting radiopharmaceutical therapeutic agent ( The RBE was measured in mice using femur marrow cellularity as the biological endpoint. External beam radiation therapy (EBRT), delivered by a small-animal radiation research platform was used as the reference radiation. Alpha-particle emissions were delivered by The dose response for EBRT and Because hematologic toxicity is dose limiting in almost all antibody-based RPT, in vivo measurements of RBE are important in helping identify an initial administered activity in phase 1 escalation trials. Applying the RBE2 and assuming typical antibody clearance kinetics (biological half-life of 48 hours), using a modified blood-based dosimetry method, an average administered activity of approximately 185.5 MBq (5.0 mCi) per patient could be administered before hematologic toxicity is anticipated.

Identifiants

DOI: 10.1016/j.ijrobp.2022.07.1842 PMID: 35926719
pubmed: 35926719
pii: S0360-3016(22)02599-8
doi: 10.1016/j.ijrobp.2022.07.1842
pii:
doi:

Substances chimiques

Lead 2P299V784P
Antibodies, Monoclonal 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

518-528

Subventions

Organisme : NCI NIH HHS
ID : R01 CA116477
Pays : United States

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Ioanna Liatsou (I)

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: iliatso1@jhmi.edu.

Anders Josefsson (A)

Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Jing Yu (J)

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Angel Cortez (A)

Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Remco Bastiaannet (R)

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Esteban Velarde (E)

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Kaori Davis (K)

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Cory Brayton (C)

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Hao Wang (H)

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Julien Torgue (J)

ORANO Med, Plano, Texas.

Robert F Hobbs (RF)

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.

George Sgouros (G)

Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Bone Marrow Relative Biological Effectiveness for a
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Bone Marrow Relative Biological Effectiveness for a
questionsmedicales.fr › Environnement et santé publique › Santé publique › Hygiène radiologique › Dose de rayonnement › Efficacité biologique relative › Bone Marrow Relative Biological Effectiveness for a
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Moelle osseuse › Bone Marrow Relative Biological Effectiveness for a
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Plomb › Bone Marrow Relative Biological Effectiveness for a
questionsmedicales.fr › Techniques d'investigation › Radiométrie › Bone Marrow Relative Biological Effectiveness for a
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Bone Marrow Relative Biological Effectiveness for a