The expression pattern of endometrial receptivity genes is desynchronized between endometrium and matched endometriomas.

Endometriosis / pathology Endometrium / metabolism Epithelium / metabolism Female Humans Menstrual Cycle / genetics
Endometrioma Endometriosis Menstrual cycle Receptivity genes Synchronicity beREADY test

Journal

Reproductive biomedicine online
ISSN: 1472-6491
Titre abrégé: Reprod Biomed Online
Pays: Netherlands
ID NLM: 101122473

Informations de publication

Date de publication:
10 2022
Historique:
received: 08 02 2022
revised: 16 05 2022
accepted: 31 05 2022
pubmed: 5 8 2022
medline: 7 10 2022
entrez: 4 8 2022
Statut: ppublish

Résumé

Are paired samples of endometrium and ovarian endometriomas synchronous with each other throughout the menstrual cycle? The expression levels of 57 endometrial receptivity-associated genes were determined from matched endometrial and endometrioma samples (n=31) collected from women with endometriosis throughout the menstrual cycle. The expression profile of endometrial receptivity genes divided endometrial samples according to their menstrual cycle phase. Endometrioma samples grouped together irrespective of the menstrual cycle phase and formed a cluster distinct from endometrial samples. Pairwise comparison showed 21, 16, 33 and 23 differentially expressed genes (adjusted P < 0.001-0.05) between the lesions and endometria collected in the proliferative, early-secretory, mid-secretory and late-secretory menstrual cycle phases, respectively, confirming the distinct expression profiles of endometrium and endometrioma. No menstrual cycle synchronicity was found between matched eutopic and ectopic endometrium, suggesting that the concept of cycling endometrial tissue inside the endometrioma should be revised.

Identifiants

DOI: 10.1016/j.rbmo.2022.05.028 PMID: 35927210
pubmed: 35927210
pii: S1472-6483(22)00409-6
doi: 10.1016/j.rbmo.2022.05.028
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

713-720

Informations de copyright

Copyright © 2022 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

Auteurs

Merli Saare (M)

Competence Centre on Health Technologies Tartu, Estonia; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu Tartu, Estonia. Electronic address: merli.saare@ut.ee.

Ankita Lawarde (A)

Competence Centre on Health Technologies Tartu, Estonia; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu Tartu, Estonia.

Vijayachitra Modhukur (V)

Competence Centre on Health Technologies Tartu, Estonia; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu Tartu, Estonia.

Iveta Mikeltadze (I)

Haematology and Oncology Clinic, Department of Oncosurgery, Tartu University Hospital Tartu, Estonia.

Helle Karro (H)

Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu Tartu, Estonia; Women's Clinic, Tartu University Hospital Tartu, Estonia.

Ave Minajeva (A)

Department of Pathological Anatomy and Forensic Medicine, Institute of Biomedicine and Translational Medicine, University of Tartu Tartu, Estonia.

Andres Salumets (A)

Competence Centre on Health Technologies Tartu, Estonia; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu Tartu, Estonia; Division of Obstetrics and Gynecology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet Stockholm, Sweden; Institute of Genomics, University of Tartu Tartu, Estonia.

Maire Peters (M)

Competence Centre on Health Technologies Tartu, Estonia; Department of Obstetrics and Gynecology, Institute of Clinical Medicine, University of Tartu Tartu, Estonia.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies génitales › Maladies de l'appareil génital féminin › Endométriose › The expression pattern of endometrial...
questionsmedicales.fr › Appareil urogénital › Système génital › Système génital de la femme › Utérus › Endomètre › The expression pattern of endometrial...
questionsmedicales.fr › Tissus › Épithélium › The expression pattern of endometrial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The expression pattern of endometrial...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Cycle menstruel › The expression pattern of endometrial...