Characterizing the evolution of oculomotor and vestibulo-ocular function over time in children and adolescents after a mild traumatic brain injury.
assessment
mild traumatic brain injuries
oculomotor
pediatric
vestibulo-ocular reflex (VOR)
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
03
2022
accepted:
28
06
2022
entrez:
5
8
2022
pubmed:
6
8
2022
medline:
6
8
2022
Statut:
epublish
Résumé
Impairments to oculomotor (OM) and vestibulo-ocular reflex (VOR) function following pediatric mTBI have been demonstrated but are poorly understood. Such impairments can be associated with more negative prognosis, affecting physical and mental wellbeing, emphasizing the need to more fully understand how these evolve. to determine i) the extent to which performance on clinical and computerized tests of OM and VOR function varies over time in children and adolescents at 21 days, 3-, and 6-months post-mTBI; ii) the proportion of children and adolescents with mTBI presenting with abnormal scores on these tests at each timepoint. Prospective longitudinal design. Tertiary care pediatric hospital. 36 participants with mTBI aged 6 to18. Participants were assessed on a battery of OM and VOR tests within 21 days, at 3- and 6-months post injury. Clinical measures Generalized estimating equations (parameter estimates and odd ratios) estimated the effect of time. Proportions above and below normal cut-off values were determined. Our sample consisted of 52.8% females [mean age 13.98 (2.4) years, assessed on average 19.07 (8-33) days post-injury]. Older children performed better on visual motion sensitivity (OR 1.43, Results indicate impairments to the VOR pathway may be present and driving symptom provocation. Vertical smooth pursuit and saccade findings underline the need to include these tasks in test batteries to comprehensively assess the integrity of OM and vestibular systems post-mTBI. Findings demonstrate 1) added value in including symptom and performance-based measures in when OM and VOR assessments; 2) the relative stability of constructs measured beyond 3 months post mTBI.
Sections du résumé
Background
UNASSIGNED
Impairments to oculomotor (OM) and vestibulo-ocular reflex (VOR) function following pediatric mTBI have been demonstrated but are poorly understood. Such impairments can be associated with more negative prognosis, affecting physical and mental wellbeing, emphasizing the need to more fully understand how these evolve.
Objectives
UNASSIGNED
to determine i) the extent to which performance on clinical and computerized tests of OM and VOR function varies over time in children and adolescents at 21 days, 3-, and 6-months post-mTBI; ii) the proportion of children and adolescents with mTBI presenting with abnormal scores on these tests at each timepoint.
Design
UNASSIGNED
Prospective longitudinal design.
Setting
UNASSIGNED
Tertiary care pediatric hospital.
Participants
UNASSIGNED
36 participants with mTBI aged 6 to18.
Procedures
UNASSIGNED
Participants were assessed on a battery of OM and VOR tests within 21 days, at 3- and 6-months post injury.
Outcome measures
UNASSIGNED
Clinical measures
Analysis
UNASSIGNED
Generalized estimating equations (parameter estimates and odd ratios) estimated the effect of time. Proportions above and below normal cut-off values were determined.
Results
UNASSIGNED
Our sample consisted of 52.8% females [mean age 13.98 (2.4) years, assessed on average 19.07 (8-33) days post-injury]. Older children performed better on visual motion sensitivity (OR 1.43,
Discussion
UNASSIGNED
Results indicate impairments to the VOR pathway may be present and driving symptom provocation. Vertical smooth pursuit and saccade findings underline the need to include these tasks in test batteries to comprehensively assess the integrity of OM and vestibular systems post-mTBI.
Implications
UNASSIGNED
Findings demonstrate 1) added value in including symptom and performance-based measures in when OM and VOR assessments; 2) the relative stability of constructs measured beyond 3 months post mTBI.
Identifiants
pubmed: 35928133
doi: 10.3389/fneur.2022.904593
pmc: PMC9344998
doi:
Types de publication
Journal Article
Langues
eng
Pagination
904593Informations de copyright
Copyright © 2022 Crampton, Schneider, Grilli, Chevignard, Katz-Leurer, Beauchamp, Debert and Gagnon.
Références
J Sci Med Sport. 2019 Dec;22(12):1292-1297
pubmed: 31521485
J Neurol Phys Ther. 2010 Jun;34(2):87-93
pubmed: 20588094
Curr Sports Med Rep. 2019 Mar;18(3):82-92
pubmed: 30855306
Curr Opin Pediatr. 2006 Aug;18(4):376-82
pubmed: 16914990
JAMA Pediatr. 2015 Dec;169(12):1132-40
pubmed: 26457403
Prog Neurobiol. 1993 Oct;41(4):435-72
pubmed: 8210413
Eur J Paediatr Neurol. 2009 Jul;13(4):362-6
pubmed: 18799334
Int J Sports Med. 2018 Feb;39(2):141-147
pubmed: 29190849
J Athl Train. 2015 Nov;50(11):1182-9
pubmed: 26509684
CNS Neurosci Ther. 2016 Jan;22(1):15-24
pubmed: 26452639
Am J Sports Med. 2014 Oct;42(10):2479-86
pubmed: 25106780
Int J Sports Phys Ther. 2017 Apr;12(2):227-232
pubmed: 28515977
J Pediatr. 2021 Dec;239:193-199
pubmed: 34450120
PM R. 2011 Oct;3(10 Suppl 2):S369-79
pubmed: 22035679
Front Neurol. 2015 Jul 08;6:154
pubmed: 26217301
Phys Ther Sport. 2020 Mar;42:68-74
pubmed: 31935640
Eye (Lond). 2015 Feb;29(2):163-70
pubmed: 25412719
Pituitary. 2019 Jun;22(3):270-282
pubmed: 30929221
J Neurophysiol. 2000 Sep;84(3):1599-613
pubmed: 10980030
J Neurosci. 2013 Feb 13;33(7):3221-7
pubmed: 23407975
J Pediatr. 2015 May;166(5):1221-5
pubmed: 25748568
Orthop J Sports Med. 2017 Dec 11;5(12):2325967117745033
pubmed: 29276716
Am J Sports Med. 2018 May;46(6):1475-1480
pubmed: 29513549
Neuroscience. 2015 Dec 17;311:484-9
pubmed: 26518461
Clin J Sport Med. 2018 Mar;28(2):139-145
pubmed: 29064869
J Neurol. 2019 Sep;266(Suppl 1):65-73
pubmed: 31087161
Br J Neurosurg. 2002 Jun;16(3):220-42
pubmed: 12201393
Am J Sports Med. 2016 Jun;44(6):1400-6
pubmed: 26980845
Otol Neurotol. 2016 Jun;37(5):545-52
pubmed: 27002314
J Neurol Phys Ther. 2018 Jul;42(3):142-148
pubmed: 29864101
J Vestib Res. 2011;21(5):277-88
pubmed: 22101298
Phys Ther Sport. 2014 Aug;15(3):181-8
pubmed: 24295546
Acad Emerg Med. 2015 Jul;22(7):872-7
pubmed: 26111921
J Neurosurg Pediatr. 2017 Jan;19(1):38-45
pubmed: 27689244
Clin Pediatr (Phila). 2016 Mar;55(3):260-7
pubmed: 26156977
Concussion. 2019 Jul 25;4(1):CNC60
pubmed: 31467684
J Neurophysiol. 2002 May;87(5):2337-57
pubmed: 11976372
Brain Inj. 2009 Mar;23(3):213-9
pubmed: 19205957
Otol Neurotol. 2007 Jan;28(1):68-73
pubmed: 17106431
J Trauma Nurs. 2006 Apr-Jun;13(2):58-65
pubmed: 16884134
Pediatrics. 2016 Jul;138(1):
pubmed: 27325635
Trends Neurosci. 2012 Mar;35(3):185-96
pubmed: 22245372
Optom Vis Sci. 2017 Jan;94(1):96-100
pubmed: 27391530
J Neurotrauma. 2008 Jul;25(7):719-38
pubmed: 18627252
Cereb Cortex. 2003 Sep;13(9):994-1007
pubmed: 12902399
J Neurol. 2017 Oct;264(Suppl 1):55-62
pubmed: 28315957
Clin J Sport Med. 2019 Sep;29(5):361-367
pubmed: 31460948
Semin Ophthalmol. 2017;32(1):144-152
pubmed: 27805468
J Rehabil Med. 2004 Feb;(43 Suppl):113-25
pubmed: 15083875
Brain Inj. 2019;33(2):105-110
pubmed: 30403884
Am J Sports Med. 2017 Feb;45(2):474-479
pubmed: 27789472
J Neurosurg Pediatr. 2015 Sep;16(3):248-55
pubmed: 26031619
Injury. 1979 Feb;10(3):225-30
pubmed: 759371
Clin Sports Med. 2011 Jan;30(1):133-44, x
pubmed: 21074088
Laryngoscope Investig Otolaryngol. 2017 Apr 12;2(4):157-165
pubmed: 28894835
BMJ Open. 2018 Jul 6;8(7):e020884
pubmed: 29982209
Musculoskelet Sci Pract. 2018 Apr;34:8-13
pubmed: 29197811
Appl Neuropsychol Child. 2021 Apr 24;:1-7
pubmed: 33896282
Clin Neuropsychol. 2017 Jan;31(1):138-153
pubmed: 27758158
Brain Connect. 2014 Mar;4(2):145-56
pubmed: 24564422
J Neurophysiol. 2004 May;91(5):1919-33
pubmed: 15069088
Sports Health. 2019 Nov/Dec;11(6):479-485
pubmed: 31411942
Exp Eye Res. 2019 Jun;183:38-45
pubmed: 30171857