Effect of inotropic agents on oxygenation and cerebral perfusion in acute brain injury.
acute brain injury
brain oxygenation
cerebral blood flow
hemodynamics
inotropic agents
Journal
Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899
Informations de publication
Date de publication:
2022
2022
Historique:
received:
07
06
2022
accepted:
28
06
2022
entrez:
5
8
2022
pubmed:
6
8
2022
medline:
6
8
2022
Statut:
epublish
Résumé
Tissue hypoxia and insufficient energy delivery is one of the mechanisms behind the occurrence of several complications in acute brain injured patients. Several interventions can improve cerebral oxygenation; however, the effects of inotropic agents remain poorly characterized. Retrospective analysis including patients suffering from acute brain injury and monitored with brain oxygen pressure (PbtO A total of 35 patients were included in this study. Most of them (31/35, 89%) suffered from non-traumatic subarachnoid hemorrhage (SAH). Compared with baseline values [20 (14-24) mmHg], PbtO In this study, inotropic administration significantly increased brain oxygenation in one third of brain injured patients, especially when tissue hypoxia was present at baseline. Future studies should highlight the role of inotropic agents in the management of tissue hypoxia in this setting.
Identifiants
pubmed: 35928138
doi: 10.3389/fneur.2022.963562
pmc: PMC9343780
doi:
Types de publication
Journal Article
Langues
eng
Pagination
963562Informations de copyright
Copyright © 2022 Coppalini, Duvigneaud, Diosdado, Migliorino, Schuind, Creteur, Taccone and Gouvêa Bogossian.
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