Nitric Oxide on Extracorporeal Life Support-Circuit Modifications for a Safe Therapy.
circuit modification
extracorporeal life support
extracorporeal membrane oxygenation
inflammation
nitric oxide
platelet activation
pressure relief valve.
thrombosis
Journal
The journal of extra-corporeal technology
ISSN: 0022-1058
Titre abrégé: J Extra Corpor Technol
Pays: France
ID NLM: 0267637
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
17
01
2022
accepted:
14
05
2022
entrez:
5
8
2022
pubmed:
6
8
2022
medline:
9
8
2022
Statut:
ppublish
Résumé
Nitric oxide (NO) incorporation into the sweep gas of the extracorporeal life support (ECLS) circuit has been proposed as a strategy to ameliorate the insults caused by the systemic inflammatory response. This technical study describes circuit modifications allowing nitric oxide to be incorporated into the circuit and describing and validating the oxygenator sweep flow rates necessary to achieve consistent safe delivery of the therapy. For patients requiring sweep rates less than 2 L/min, a simplified setup, incorporating a pressure relief valve/low flow meter in the gas delivery line, was placed in line between the blender/NO injector module and the NO sampling port/oxygenator. This setup allows titration of sweep to low flows without the need to blend in CO
Identifiants
pubmed: 35928341
doi: 10.1182/ject-142-147
pii: 2200005
pmc: PMC9302404
doi:
Substances chimiques
Nitric Oxide
31C4KY9ESH
Nitrogen Dioxide
S7G510RUBH
Types de publication
Journal Article
Langues
eng
Pagination
142-147Informations de copyright
© Copyright 2022 AMSECT.
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