Investigation of Concurrent Pneumococcal Meningitis in Two Children Attending the Same Day-Care Center.

Only a few clusters of invasive pneumococcal disease have been described globally in children, and most of these cases occurred before pneumococcal vaccination implementation. Two unusual cases of pneumococcal meningitis, occurring in the same daycare center over a 3-day period, were reported. Both cerebrospinal fluid (CSF) were sent to the National reference center for pneumococci. In addition, we decided to perform a pneumococcal carriage study on all children and staff of the daycare center to analyze the pneumococcal serotypes circulating in this DCC and to discuss an antibiotic chemoprophylaxis. CSF culture was positive for pneumococcus, and serotype 25A was identified by latex agglutination. The second case had negative CSF culture, but CSF antigen test and gene amplification results were positive for

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Copyright © 2022 Rybak, Varon, Masson, Etchevers, Levy-Brühl, Ouldali, Levy and Cohen.

Déclaration de conflit d'intérêts

Grants for ACTIV were received from GlaxoSmithKline (GSK), MSD, Pfizer, and Sanofi outside the submitted work. AR reports grants from AFPA, and travel grants from Pfizer and AstraZeneca outside the submitted work. NO reports travel grants from Pfizer, Sanofi, and GSK, and grants from the European Society for Paediatric Infectious Diseases outside the submitted work. EV reports grants from French Public Health Agency to the institution, and grants to the institution from Pfizer and MSD, outside the submitted work. CL reports grants to the institution ACTIV from GSK, Sanofi, Pfizer, and Merck, and personal fees and nonfinancial support from Pfizer and Merck, outside the conduct of the study. RC reports grants to the institution ACTIV, personal fees, and nonfinancial support from GSK, Sanofi, Pfizer, and Merck, outside the submitted work. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.