Combining PET with MRI to improve predictions of progression from mild cognitive impairment to Alzheimer's disease: an exploratory radiomic analysis study.
Cox model
Mild cognitive impairment (MCI)
magnetic resonance imaging (MRI)
positron emission tomography (PET)
radiology
Journal
Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978
Informations de publication
Date de publication:
May 2022
May 2022
Historique:
received:
18
08
2021
accepted:
19
12
2021
entrez:
5
8
2022
pubmed:
6
8
2022
medline:
6
8
2022
Statut:
ppublish
Résumé
This study aimed to explore the potential of a combination of 18F-fluorodeoxyglucose positron emission tomography ( This study enrolled 377 patients with MCI and 94 healthy control participants from 2 medical centers. Enrolment was based on the patients' brain MRI and PET images. Radiomic analysis was performed to evaluate the predictive performance of dual-modality The C-indices for the two test datasets were 0.77 and 0.80 for dual-modality These results indicate the value of imaging features in monitoring the progress of MCI in populations at high risk of developing AD. However, the incremental benefit of combining
Sections du résumé
Background
UNASSIGNED
This study aimed to explore the potential of a combination of 18F-fluorodeoxyglucose positron emission tomography (
Methods
UNASSIGNED
This study enrolled 377 patients with MCI and 94 healthy control participants from 2 medical centers. Enrolment was based on the patients' brain MRI and PET images. Radiomic analysis was performed to evaluate the predictive performance of dual-modality
Results
UNASSIGNED
The C-indices for the two test datasets were 0.77 and 0.80 for dual-modality
Conclusions
UNASSIGNED
These results indicate the value of imaging features in monitoring the progress of MCI in populations at high risk of developing AD. However, the incremental benefit of combining
Identifiants
pubmed: 35928737
doi: 10.21037/atm-21-4349
pii: atm-10-09-513
pmc: PMC9347042
doi:
Types de publication
Journal Article
Langues
eng
Pagination
513Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Informations de copyright
2022 Annals of Translational Medicine. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://atm.amegroups.com/article/view/10.21037/atm-21-4349/coif). The authors have no conflicts of interest to declare.
Références
Eur Radiol. 2017 Sep;27(9):3716-3724
pubmed: 28289940
Handb Clin Neurol. 2019;167:191-227
pubmed: 31753134
J Alzheimers Dis. 2016 Aug 10;54(1):359-71
pubmed: 27567818
Alzheimers Res Ther. 2018 Oct 30;10(1):112
pubmed: 30376881
Ageing Res Rev. 2016 Sep;30:25-48
pubmed: 26827786
Ann Neurol. 2009 Aug;66(2):200-8
pubmed: 19743450
Front Aging Neurosci. 2019 Nov 21;11:323
pubmed: 31824302
Ther Adv Neurol Disord. 2019 Mar 29;12:1756286419838682
pubmed: 30956687
J Stat Softw. 2011 Mar;39(5):1-13
pubmed: 27065756
Sci Bull (Beijing). 2020 Jul 15;65(13):1103-1113
pubmed: 36659162
Nat Rev Clin Oncol. 2017 Dec;14(12):749-762
pubmed: 28975929
J Stat Softw. 2010;33(1):1-22
pubmed: 20808728
Front Aging Neurosci. 2018 Sep 25;10:290
pubmed: 30319396
J Nucl Med. 2019 Jun;60(6):837-843
pubmed: 30389825
Comput Biol Med. 2018 Nov 1;102:30-39
pubmed: 30245275
Neuroimage. 2020 Feb 1;206:116290
pubmed: 31634545
Arch Neurol. 2009 Dec;66(12):1447-55
pubmed: 20008648
Neuropsychopharmacology. 2020 Jan;45(2):358-366
pubmed: 31634898
Curr Alzheimer Res. 2017;14(2):127-142
pubmed: 27357645
Front Neurosci. 2019 May 07;13:435
pubmed: 31133781
Biomed Res Int. 2015;2015:583931
pubmed: 26346648
J Neurol Neurosurg Psychiatry. 2016 May;87(5):476-84
pubmed: 26001840
Front Hum Neurosci. 2017 Feb 06;11:33
pubmed: 28220065
Phys Med Biol. 2015 Jul 21;60(14):5471-96
pubmed: 26119045
Front Aging Neurosci. 2019 Dec 03;11:326
pubmed: 31866850
Cell. 2019 Oct 3;179(2):312-339
pubmed: 31564456
Front Neurosci. 2019 Jan 11;12:1045
pubmed: 30686995
Eur Radiol Exp. 2018 Nov 14;2(1):36
pubmed: 30426318
Ageing Res Rev. 2016 Sep;30:73-84
pubmed: 26876244
Bioinformatics. 2005 Jul 1;21(13):3001-8
pubmed: 15814556
Front Neurol. 2018 Jul 26;9:618
pubmed: 30093881
Arch Neurol. 2001 Dec;58(12):1985-92
pubmed: 11735772