External validation of the Predicting Asthma Risk in Children tool in a clinical cohort.
PARC
SPAC
asthma
children
external validation
prediction
preschool
risk
wheeze
Journal
Pediatric pulmonology
ISSN: 1099-0496
Titre abrégé: Pediatr Pulmonol
Pays: United States
ID NLM: 8510590
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
17
06
2022
accepted:
31
07
2022
pubmed:
6
8
2022
medline:
19
10
2022
entrez:
5
8
2022
Statut:
ppublish
Résumé
The Predicting Asthma Risk in Children (PARC) tool uses questionnaire-based respiratory symptoms collected from preschool children to predict asthma risk 5 years later. The tool was developed and validated in population cohorts but not validated using a clinical cohort. We aimed to externally validate the PARC tool in a pediatric pulmonology clinic setting. The Swiss Paediatric Airway Cohort (SPAC) is a prospective cohort of children seen in pediatric pulmonology clinics across Switzerland. We included children aged 1-6 years with cough or wheeze at baseline who completed the 2-year follow-up questionnaire. The outcome was defined as current wheeze plus use of asthma medication. We assessed performance using: sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV), area under the curve (AUC), scaled Brier's score, and Nagelkerke's R Among 346 children included, 125 (36%) reported the outcome after 2 years. At a PARC score of 4: sensitivity was higher (95% vs. 79%), specificity lower (14% vs. 57%), and NPV and PPV comparable (0.84 vs. 0.87 and 0.37 vs. 0.42) in SPAC versus LRC. AUC (0.71 vs. 0.78), R The PARC tool shows some clinical utility, particularly for ruling out the development of asthma in young children, but performance limitations highlight the need for new prediction tools to be developed specifically for the clinical setting.
Identifiants
pubmed: 35929421
doi: 10.1002/ppul.26088
pmc: PMC9804745
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2715-2723Informations de copyright
© 2022 The Authors. Pediatric Pulmonology published by Wiley Periodicals LLC.
Références
J Pers Med. 2022 Jan 08;12(1):
pubmed: 35055391
BMC Pulm Med. 2012 Oct 16;12:65
pubmed: 23067313
J Asthma. 2011 Dec;48(10):1015-21
pubmed: 22022892
Lancet. 2021 Oct 30;398(10311):1569-1580
pubmed: 34755626
Thorax. 2009 Jun;64(6):476-83
pubmed: 19237391
Int J Epidemiol. 2007 Oct;36(5):977-85
pubmed: 17911154
Pediatr Pulmonol. 2022 Nov;57(11):2715-2723
pubmed: 35929421
J Allergy Clin Immunol. 2009 Nov;124(5):903-10.e1-7
pubmed: 19665765
J Allergy Clin Immunol. 2014 Jan;133(1):111-8.e1-13
pubmed: 23891353
Int J Tuberc Lung Dis. 2006 Feb;10(2):125-32
pubmed: 16499249
J Allergy Clin Immunol Pract. 2019 Mar;7(3):943-953.e4
pubmed: 30312804
J Allergy Clin Immunol. 2019 May;143(5):1803-1810.e2
pubmed: 30554722
Pediatr Pulmonol. 2021 Oct;56(10):3183-3188
pubmed: 34320686
Pediatr Pulmonol. 2011 Dec;46(12):1175-81
pubmed: 21626716
Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1403-6
pubmed: 11029352
Lancet. 2018 Nov 10;392(10159):1736-1788
pubmed: 30496103
Ann Intern Med. 2019 Jan 1;170(1):51-58
pubmed: 30596875
Eur Respir J. 2003 Nov;22(5):767-71
pubmed: 14621083
Clin Exp Allergy. 2019 Apr;49(4):410-418
pubmed: 30657220
PLoS One. 2014 Dec 23;9(12):e115852
pubmed: 25536057
J Clin Epidemiol. 2005 May;58(5):475-83
pubmed: 15845334
Pediatr Pulmonol. 2017 Oct;52(10):1250-1259
pubmed: 28815996
Pediatr Pulmonol. 2017 Jun;52(6):729-736
pubmed: 28076664
BMJ Open. 2019 Apr 24;9(4):e025611
pubmed: 31023756
Allergy. 2013 Apr;68(4):531-8
pubmed: 23414302
Sci Rep. 2022 Jan 25;12(1):1315
pubmed: 35079067
ERJ Open Res. 2018 Nov 20;4(4):
pubmed: 30474037