Melanin-concentrating hormone regulates the hypercapnic chemoreflex by acting in the lateral hypothalamic area.
MCH
central chemoreception
hypercapnia
Journal
Experimental physiology
ISSN: 1469-445X
Titre abrégé: Exp Physiol
Pays: England
ID NLM: 9002940
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
20
01
2022
accepted:
22
07
2022
pubmed:
6
8
2022
medline:
4
11
2022
entrez:
5
8
2022
Statut:
ppublish
Résumé
What is the central question of this study? Melanin-concentrating hormone (MCH) suppresses the hypercapnic chemoreflex: what is the mechanism by which this effect is produced? What is the main finding and its importance? MCH acting in the lateral hypothalamic area but not in the locus coeruleus in rats, in the light period, attenuates the hypercapnic chemoreflex. The data provide new insight into the role of MCH in the modulation of the hypercapnic ventilatory response. Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide involved in a broad range of homeostatic functions including regulation of the hypercapnic chemoreflex. We evaluated whether MCH modulates the hypercapnic ventilatory response by acting in the lateral hypothalamic area (LHA) and/or in the locus coeruleus (LC). Here, we measured pulmonary ventilation (
Substances chimiques
melanin-concentrating hormone
67382-96-1
Carbon Dioxide
142M471B3J
Hypothalamic Hormones
0
Banques de données
figshare
['10.6084/m9.figshare.20453979.v1']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1298-1311Informations de copyright
© 2022 The Authors. Experimental Physiology © 2022 The Physiological Society.
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