Multi-cohort and longitudinal Bayesian clustering study of stage and subtype in Alzheimer's disease.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
05 08 2022
05 08 2022
Historique:
received:
30
04
2021
accepted:
18
07
2022
entrez:
5
8
2022
pubmed:
6
8
2022
medline:
10
8
2022
Statut:
epublish
Résumé
Understanding Alzheimer's disease (AD) heterogeneity is important for understanding the underlying pathophysiological mechanisms of AD. However, AD atrophy subtypes may reflect different disease stages or biologically distinct subtypes. Here we use longitudinal magnetic resonance imaging data (891 participants with AD dementia, 305 healthy control participants) from four international cohorts, and longitudinal clustering to estimate differential atrophy trajectories from the age of clinical disease onset. Our findings (in amyloid-β positive AD patients) show five distinct longitudinal patterns of atrophy with different demographical and cognitive characteristics. Some previously reported atrophy subtypes may reflect disease stages rather than distinct subtypes. The heterogeneity in atrophy rates and cognitive decline within the five longitudinal atrophy patterns, potentially expresses a complex combination of protective/risk factors and concomitant non-AD pathologies. By alternating between the cross-sectional and longitudinal understanding of AD subtypes these analyses may allow better understanding of disease heterogeneity.
Identifiants
pubmed: 35931678
doi: 10.1038/s41467-022-32202-6
pii: 10.1038/s41467-022-32202-6
pmc: PMC9355993
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4566Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : CIHR
Pays : Canada
Informations de copyright
© 2022. The Author(s).
Références
J Nucl Med. 2013 Jan;54(1):70-7
pubmed: 23166389
Lancet Neurol. 2011 Sep;10(9):785-96
pubmed: 21802369
Diabetes Obes Metab. 2019 Mar;21(3):560-568
pubmed: 30284381
Trends Cogn Sci. 2019 Jul;23(7):584-601
pubmed: 31153774
Brain Commun. 2021 Jan 22;3(1):fcaa238
pubmed: 33615218
Neuroimage. 2008 Aug 15;42(2):559-67
pubmed: 18572417
Aging (Albany NY). 2020 Jul 9;12(13):12622-12647
pubmed: 32644944
Neurobiol Aging. 2018 Oct;70:18-29
pubmed: 29935417
Pediatr Pulmonol. 2019 Aug;54(8):1267-1276
pubmed: 31172683
Neuropathology. 2000 Mar;20(1):31-7
pubmed: 10935434
Nat Commun. 2018 Oct 15;9(1):4273
pubmed: 30323170
Res Nurs Health. 2019 Apr;42(2):119-127
pubmed: 30710373
Front Neuroinform. 2014 Jan 06;7:49
pubmed: 24432000
Med Care. 2017 Nov;55(11):956-964
pubmed: 28922296
Lancet Neurol. 2012 Oct;11(10):868-77
pubmed: 22951070
Alzheimers Res Ther. 2013 Jan 09;5(1):1
pubmed: 23302773
Nat Commun. 2019 Jun 4;10(1):2353
pubmed: 31164641
PLoS One. 2017 Aug 1;12(8):e0178798
pubmed: 28763447
Alzheimers Dement. 2018 Nov;14(11):1470-1481
pubmed: 29499171
Biol Psychiatry. 2020 Jul 1;88(1):70-82
pubmed: 32201044
Neurobiol Aging. 2010 Aug;31(8):1275-83
pubmed: 20472326
Sci Rep. 2018 May 30;8(1):8431
pubmed: 29849029
Neurology. 2008 Sep 2;71(10):743-9
pubmed: 18765650
Sci Rep. 2018 Aug 2;8(1):11592
pubmed: 30072774
Stat Med. 2019 May 20;38(11):1903-1917
pubmed: 30663113
Neurology. 2007 Dec 11;69(24):2197-204
pubmed: 17568013
J Alzheimers Dis. 2021;79(1):423-431
pubmed: 33285634
Brain. 2020 Dec 1;143(12):3776-3792
pubmed: 33439986
Brain. 2021 Nov 29;144(10):2946-2953
pubmed: 33892488
Neurology. 2020 Mar 10;94(10):436-448
pubmed: 32047067
Neurobiol Aging. 2018 May;65:98-108
pubmed: 29455029
Stat Methods Med Res. 2018 Jul;27(7):2060-2080
pubmed: 27789653
Alzheimers Dement. 2018 Aug;14(8):1077-1087
pubmed: 29753531
Sci Rep. 2019 Aug 6;9(1):11353
pubmed: 31388019
Ann Neurol. 2018 Feb;83(2):248-257
pubmed: 29323751
Alzheimers Dement. 2017 Mar;13(3):205-216
pubmed: 27697430
Neurology. 1995 Jan;45(1):17-23
pubmed: 7824110
Int Psychogeriatr. 2009 Aug;21(4):672-87
pubmed: 19470201
Res Nurs Health. 2020 Sep;43(5):443-452
pubmed: 32866350
Neuropsychologia. 2009 Aug;47(10):2015-28
pubmed: 19467352
Neuroradiology. 2007 Dec;49(12):967-76
pubmed: 17955233
Neuroimage. 2019 May 15;192:166-177
pubmed: 30844504
Eur J Nucl Med Mol Imaging. 2017 May;44(5):850-857
pubmed: 27966045
Nat Med. 2021 May;27(5):871-881
pubmed: 33927414