Dry heat sterilization modelling for spacecraft applications.
Bacillus
dry heat
interplanetary
spacecraft
spores
sterilization
Journal
Journal of applied microbiology
ISSN: 1365-2672
Titre abrégé: J Appl Microbiol
Pays: England
ID NLM: 9706280
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
revised:
23
06
2022
received:
19
02
2022
accepted:
11
07
2022
pubmed:
7
8
2022
medline:
22
10
2022
entrez:
6
8
2022
Statut:
ppublish
Résumé
Inactivation processes using heat are widely used for disinfection and sterilization. Dry heat sterilization of spacecraft equipment has been the preferred microbial inactivation method as part of interplanetary travel protection strategies. An antimicrobial model, based on temperature and exposure time based on experimental data, was developed to provide reliable sterilization processes to be used for interplanetary applications. Bacillus atrophaeus spores, traditionally used to challenge dry heat sterilization processes, were tested over a range of temperatures in comparison with spores of Bacillus canaveralius that have been shown to have a higher heat resistance profile. D-value and Z-values were determined and used to develop a mathematical model for parametric sterilization applications. The impact of the presence of a contaminating soil, representative of Mars dust, was also tested to verify the practical application of the model to reduce the risk of microbial contamination in such environments. The sterilization model developed can be used as an intrinsic part of risk reduction strategies for interplanetary protection. Forward and backward planetary protection strategies to reduce the risks of microbial contamination during interplanetary exploration and research is an important consideration. The development of a modern sterilization model, with consideration of microorganisms identified with higher levels of heat resistance than traditionally deployed in terrestrial applications, allows for the consideration of optimal inactivation processes to define minimum criteria for engineering design. The ability to inactivate living microorganisms, as well as to degrade biomolecules, provides a reliable method to reduce the risk of known and potentially unknown contaminants in future applications.
Substances chimiques
Dust
0
Soil
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2893-2901Subventions
Organisme : NASA
ID : 80NM0018D0004
Pays : United States
Organisme : Microbiological Quality & Sterility Assurance, Johnson & Johnson
Organisme : NASA
ID : 80NM0018D0004
Pays : United States
Informations de copyright
© 2022 Society for Applied Microbiology.
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