Structural damage to the rat eye following long-term simulated weightlessness.
Injury
Optic nerve
Retina
Simulating weightlessness
Journal
Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
01
01
2022
revised:
14
06
2022
accepted:
18
07
2022
pubmed:
7
8
2022
medline:
30
9
2022
entrez:
6
8
2022
Statut:
ppublish
Résumé
To better perform space missions and develop human spaceflights, the eye health of astronauts is receiving increasing attention from researchers. In this study, we used prolonged tail suspension to simulate microgravity cephalad fluid shift in space to observe intraocular pressure (IOP) changes, retinal structure, and optic nerve damage in rats. We observed significant choroidal thickening and optic nerve demyelination lesions in the rats in each experimental group. At the cellular level, retinal ganglion cells (RGCs) survival was significantly reduced, optic nerve oligodendrocytes were reduced, and apoptotic factors and microglia-mediated inflammation-related factors were detected in both the retina and optic nerve. The severity of these changes increased with increasing tails suspension time. In conclusion, simulated long-term microgravity can lead to slight intraocular pressure fluctuations, choroidal thickening, reduced RGCs survival, and optic nerve demyelination in rats.
Identifiants
pubmed: 35932903
pii: S0014-4835(22)00280-9
doi: 10.1016/j.exer.2022.109200
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
109200Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.