Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis.
Amlodipine
Artesunate
Cancer
Deferasirox
Deferoxamine
Dexrazoxane
Doxorubicin
Erastin
Extramedullary hematopoiesis
Ferritinophagy
Ferroptosis
Inflammation
Iron
Metabolic syndrome
Nifedipine
Quercetin
RSL3
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
30
06
2022
revised:
25
07
2022
accepted:
02
08
2022
pubmed:
7
8
2022
medline:
14
9
2022
entrez:
6
8
2022
Statut:
ppublish
Résumé
Iron participates in myriad processes necessary to sustain life. During the past decades, great efforts have been made to understand iron regulation and function in health and disease. Indeed, iron is associated with both physiological (e.g., immune cell biology and function and hematopoiesis) and pathological (e.g., inflammatory and infectious diseases, ferroptosis and ferritinophagy) processes, yet few studies have addressed the potential functional link between iron, the aforementioned processes and extramedullary hematopoiesis, despite the obvious benefits that this could bring to clinical practice. Further investigation in this direction will shape the future development of individualized treatments for iron-linked diseases and chronic inflammatory disorders, including extramedullary hematopoiesis, metabolic syndrome, cardiovascular diseases and cancer.
Identifiants
pubmed: 35933006
pii: S1043-6618(22)00331-0
doi: 10.1016/j.phrs.2022.106386
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106386Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflict of interest.