In-vitro models of biocompatibility testing for restorative dental materials: From 2D cultures to organs on-a-chip.
Biocompatibility
Cell culture
Dental materials
Tissue chips
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
15 09 2022
15 09 2022
Historique:
received:
15
04
2022
revised:
13
07
2022
accepted:
28
07
2022
pubmed:
7
8
2022
medline:
9
9
2022
entrez:
6
8
2022
Statut:
ppublish
Résumé
Dental caries is a biofilm-mediated, diet-modulated, multifactorial and dynamic disease that affects more than 90% of adults in Western countries. The current treatment for decayed tissue is based on using materials to replace the lost enamel or dentin. More than 500 million dental restorations are placed annually worldwide, and materials used for these purposes either directly or indirectly interact with dentin and pulp tissues. The development and understanding of the effects of restorative dental materials are based on different in-vitro and in-vivo tests, which have been evolving with time. In this review, we first discuss the characteristics of the tooth and the dentin-pulp interface that are unique for materials testing. Subsequently, we discuss frequently used in-vitro tests to evaluate the biocompatibility of dental materials commonly used for restorative procedures. Finally, we present our perspective on the future directions for biological research on dental materials using tissue engineering and organs on-a-chip approaches. STATEMENT OF SIGNIFICANCE: Dental caries is still the most prevalent infectious disease globally, requiring more than 500 million restorations to be placed every year. Regrettably, the failure rates of such restorations are still high. Those rates are partially based on the fact that current platforms to test dental materials are somewhat inaccurate in reproducing critical components of the complex oral microenvironment. Thus, there is a collective effort to develop new materials while evolving the platforms to test them. In this context, the present review critically discusses in-vitro models used to evaluate the biocompatibility of restorative dental materials and brings a perspective on future directions for tissue-engineered and organs-on-a-chip platforms for testing new dental materials.
Identifiants
pubmed: 35933103
pii: S1742-7061(22)00462-7
doi: 10.1016/j.actbio.2022.07.060
pmc: PMC9814917
mid: NIHMS1860672
pii:
doi:
Substances chimiques
Composite Resins
0
Dental Materials
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-66Subventions
Organisme : NIDCR NIH HHS
ID : K01 DE030484
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026170
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE029553
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA263860
Pays : United States
Informations de copyright
Copyright © 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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