Investigating the therapeutic options for diabetes-associated male infertility as illustrated in animal experimental models.
animals
diabetes
male infertility
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
revised:
15
05
2022
received:
31
03
2022
accepted:
25
05
2022
pubmed:
9
8
2022
medline:
8
9
2022
entrez:
8
8
2022
Statut:
ppublish
Résumé
Diabetes is a rising global health concern and an increasingly common cause of male infertility. Although the definitive pathophysiological mechanisms underpinning the association between diabetes and infertility is unclear, there are several animal studies showing diabetes to be a detrimental factor on reproductive health through apoptosis, oxidative stress and impairment of steroidogenesis. Furthermore, as reflected in animal models, antidiabetic strategies and relevant treatments are beneficial in the management of infertile men with diabetes as the recovery of euglycemic status affects positively the spermatogenesis. However, the available data are still evolving and specific conclusion in human populations are not possible yet. In this review, we are discussing the current literature concerning the association of diabetes and male infertility, focusing on the therapeutic approach as illustrated in animals' models.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e14521Informations de copyright
© 2022 Wiley-VCH GmbH.
Références
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