Co-occurrence of myeloid neoplasm and plasma cell neoplasm.
Bone Marrow
Monoclonal Gammopathy of Undetermined Significance
Myelodysplastic Syndromes
Pancytopenia
Smoldering Multiple Myeloma
Journal
Autopsy & case reports
ISSN: 2236-1960
Titre abrégé: Autops Case Rep
Pays: Brazil
ID NLM: 101640070
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
02
2022
accepted:
06
07
2022
entrez:
8
8
2022
pubmed:
9
8
2022
medline:
9
8
2022
Statut:
epublish
Résumé
Co-occurrence of myelodysplastic syndrome (MDS) and plasma cell neoplasm in patients with no history of chemo and/or radiotherapy is rarely reported. Herein, we report a case of a female in her seventieth decade of life who was referred to the hospital for pancytopenia. The patient was asymptomatic and was doing well overall. Serum protein electrophoresis was remarkable for a lambda-restricted monoclonal protein (IgG) estimated at 1.8g/dL. Immunoglobulin G serum level was also elevated, and serum Kappa/Lambda free light chain ratio was decreased. At that time, a bone marrow biopsy showed myelodysplastic syndrome with excess blasts-2 (MDS-EB2) and a monoclonal plasma cell proliferation. Some studies have shown that patients with plasma cell neoplasm could be associated with an increased risk of developing MDS compared to the general population. Based on reviewing the literature, to our knowledge, the pathological mechanism of the co-occurrence of both diseases is not yet clear.
Identifiants
pubmed: 35935173
doi: 10.4322/acr.2021.393
pii: acrep133222
pmc: PMC9341343
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e2021393Informations de copyright
Copyright © 2022 The Authors.
Déclaration de conflit d'intérêts
Conflict of interest: None
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