Peripheral Neuroprotective and Immunomodulatory Effects of 5α-Reductase Inhibitors in Parkinson's Disease Models.
MPTP
dutasteride
enteric nervous system
female hormones
finasteride
gut
inflammation
mitochondria
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
16
03
2022
accepted:
27
05
2022
entrez:
8
8
2022
pubmed:
9
8
2022
medline:
9
8
2022
Statut:
epublish
Résumé
Gastrointestinal disorders in Parkinson's disease (PD) have been associated with neuronal alteration in the plexus of the gut. We previously demonstrated the immunomodulatory effect of female hormones to treat enteric neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. This study made the hypothesis of obtaining similar neuroprotection as with hormone treatments by affecting steroidogenesis with two 5α-reductase inhibitors, finasteride and dutasteride. These drugs are approved to treat benign prostatic hyperplasia and alopecia and display mitochondrial effects. In MPTP-treated mice, the dopaminergic and vasoactive intestinal peptide (VIP) neurons alteration was prevented by finasteride and dutasteride, while the increase in proinflammatory macrophages density was inhibited by dutasteride treatment but not finasteride. NF-κB response, oxidative stress, and nitric oxide and proinflammatory cytokines production
Identifiants
pubmed: 35935876
doi: 10.3389/fphar.2022.898067
pii: 898067
pmc: PMC9355275
doi:
Types de publication
Journal Article
Langues
eng
Pagination
898067Informations de copyright
Copyright © 2022 Poirier, Côté, Jarras, Litim, Lamontagne-Proulx, Al-Sweidi, Morissette, Lachhab, Pelletier, Di Paolo and Soulet.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Acta Neuropathol. 1990;79(6):581-3
pubmed: 1972853
Antioxidants (Basel). 2021 Feb 03;10(2):
pubmed: 33546471
Sci Transl Med. 2018 Oct 31;10(465):
pubmed: 30381408
Brain Behav Immun. 2015 May;46:154-67
pubmed: 25637482
Neuroendocrinology. 2016;103(3-4):300-14
pubmed: 26227546
Biochem Biophys Res Commun. 2003 Aug 29;308(3):469-73
pubmed: 12914773
Lancet Neurol. 2015 Jun;14(6):625-39
pubmed: 25987282
Neurobiol Dis. 2015 Oct;82:99-113
pubmed: 26051538
J Neurol. 2017 Aug;264(8):1583-1607
pubmed: 28054129
Cells. 2021 Jan 06;10(1):
pubmed: 33418876
Neuropharmacology. 2015 Aug;95:343-52
pubmed: 25892506
J Proteome Res. 2008 Jun;7(6):2262-9
pubmed: 18465891
Front Neuroendocrinol. 2013 Apr;34(2):132-42
pubmed: 23563222
Nat Commun. 2020 Oct 27;11(1):5430
pubmed: 33110062
Horm Mol Biol Clin Investig. 2010 Aug 1;2(3):293-9
pubmed: 25961201
Brain. 2020 Oct 1;143(10):3041-3051
pubmed: 33029617
Neurobiol Dis. 2019 Sep;129:38-43
pubmed: 31078683
Am J Physiol Gastrointest Liver Physiol. 2013 Jun 1;304(11):G949-57
pubmed: 23538492
Ann N Y Acad Sci. 1998 May;844(1):153-165
pubmed: 29090819
Front Neuroendocrinol. 2014 Aug;35(3):370-84
pubmed: 24607323
Eur J Pharmacol. 1991 Dec 12;208(4):273-86
pubmed: 1815982
J Neurogastroenterol Motil. 2018 Jul 30;24(3):469-478
pubmed: 29969861
Acta Neuropathol Commun. 2019 Mar 14;7(1):41
pubmed: 30871620
Antioxidants (Basel). 2020 Jul 08;9(7):
pubmed: 32650609
Biomed Res Int. 2015;2015:628192
pubmed: 26295044
Neurobiol Dis. 2013 Feb;50:42-8
pubmed: 23017648
Brain Res. 2008 Sep 10;1229:218-23
pubmed: 18644355
Prog Neurobiol. 2013 Jul-Aug;106-107:17-32
pubmed: 23643800
J Parkinsons Dis. 2021;11(2):529-543
pubmed: 33523018
Chang Gung Med J. 2009 Mar-Apr;32(2):140-7
pubmed: 19403003
J Neural Transm (Vienna). 2003 May;110(5):517-36
pubmed: 12721813
J Neurogastroenterol Motil. 2019 Jan 31;25(1):48-60
pubmed: 30646475
Neuropharmacology. 2021 Dec 15;201:108784
pubmed: 34555366
Neuropharmacology. 2017 May 1;117:209-218
pubmed: 28192111
J Steroid Biochem Mol Biol. 1997 Apr;61(1-2):55-64
pubmed: 9328210
Parkinsons Dis. 2016;2016:6762528
pubmed: 28050310
Adv Urol. 2012;2012:530121
pubmed: 22235201
J Neurol Neurosurg Psychiatry. 2004 Jan;75(1):165-6
pubmed: 14707335
Neuropathol Appl Neurobiol. 2007 Dec;33(6):599-614
pubmed: 17961138
Free Radic Biol Med. 2010 Feb 15;48(4):560-6
pubmed: 19969070
Gut. 2019 May;68(5):829-843
pubmed: 30554160
Neurogastroenterol Motil. 2017 May;29(5):
pubmed: 27891695
Front Aging Neurosci. 2022 Jan 07;13:782082
pubmed: 35069178
J Neurosci. 2015 Dec 16;35(50):16463-78
pubmed: 26674871
Brain Behav Immun. 2011 Aug;25(6):1143-52
pubmed: 21376805
Endocr Metab Immune Disord Drug Targets. 2012 Dec;12(4):323-32
pubmed: 23094829
J Neurosci Methods. 1995 Nov;62(1-2):121-7
pubmed: 8750093
Atherosclerosis. 2012 Dec;225(2):461-8
pubmed: 23078881
Neurology. 2004 Feb 10;62(3):411-3
pubmed: 14872022
Neuropharmacology. 2015 Oct;97:86-94
pubmed: 26006269
Exp Ther Med. 2020 Aug;20(2):1566-1574
pubmed: 32742388
Acta Neuropathol. 2012 Nov;124(5):665-80
pubmed: 22941241
Front Neurosci. 2020 Mar 10;14:157
pubmed: 32210745
Trends Biochem Sci. 2021 Apr;46(4):329-343
pubmed: 33323315
mSystems. 2020 Dec 8;5(6):
pubmed: 33293403
Mov Disord. 2019 Mar;34(3):307-316
pubmed: 30653258
FASEB J. 2003 Aug;17(11):1428-33
pubmed: 12890696
Mov Disord. 2013 May;28(5):597-604
pubmed: 23554107
J Neural Transm Suppl. 2000;(60):277-90
pubmed: 11205147
Clin Interv Aging. 2019 Feb 20;14:399-406
pubmed: 30863034
Ann Neurol. 2016 Jun;79(6):940-9
pubmed: 27015771
J Biol Chem. 1992 Apr 25;267(12):8577-83
pubmed: 1314830
Methods Enzymol. 2014;542:125-49
pubmed: 24862264
Neurobiol Aging. 2014 Oct;35(10):2347-56
pubmed: 24726471
Cell Immunol. 2015 Apr;294(2):63-9
pubmed: 25682174
Prog Neurobiol. 2019 Jun;177:73-93
pubmed: 30219247
Nature. 2018 Jul;559(7714):410-414
pubmed: 29995846
Neurobiol Aging. 2013 Mar;34(3):887-901
pubmed: 22749492
Mol Neurodegener. 2020 Jan 13;15(1):5
pubmed: 31931835
Nat Neurosci. 2020 Mar;23(3):327-336
pubmed: 32066981
Cell Mol Gastroenterol Hepatol. 2018 Apr 12;6(2):133-148
pubmed: 30023410
Drug Discov Today. 2018 Dec;23(12):1983-1989
pubmed: 30081095
Neurobiol Aging. 2016 Dec;48:61-71
pubmed: 27644075
Arch Neurol. 2002 May;59(5):807-11
pubmed: 12020264
Cell Death Differ. 2015 Mar;22(3):377-88
pubmed: 25257172
Int J Mol Sci. 2021 Apr 28;22(9):
pubmed: 33925154
J Neuroimmune Pharmacol. 2021 Sep;16(3):667-678
pubmed: 33221984
BMJ. 2019 Jan 9;364:k4810
pubmed: 30626577
J Steroid Biochem Mol Biol. 2017 Nov;174:242-256
pubmed: 28982631
Cells. 2020 Jul 14;9(7):
pubmed: 32674367
FASEB J. 2003 May;17(8):944-6
pubmed: 12626429