No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study.
depression
genetic correlation
genetic correlation analysis
mendelian randomization analysis
periodontitis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
04
2022
accepted:
27
06
2022
entrez:
8
8
2022
pubmed:
9
8
2022
medline:
10
8
2022
Statut:
epublish
Résumé
Observational and The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation. LDSC observed only weak genetic correlation (r Results do not support shared heritability or a causal connection between depression and periodontitis.
Sections du résumé
Background
Observational and
Methods
The study used summary statistics from published genome wide association studies, with sample sizes ranging from 45,563 to 797,563 individuals of European ancestry. We performed linkage disequilibrium score regression (LDSC) to estimate global correlation and used Heritability Estimation from Summary Statistics (ρ-HESS) to further examine local genetic correlation. Latent Heritable Confounder Mendelian randomization (LHC-MR), Causal Analysis using Summary Effect estimates (CAUSE), and conventional MR approaches assessed bidirectional causation.
Results
LDSC observed only weak genetic correlation (r
Conclusions
Results do not support shared heritability or a causal connection between depression and periodontitis.
Identifiants
pubmed: 35935963
doi: 10.3389/fimmu.2022.918404
pmc: PMC9355660
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
918404Informations de copyright
Copyright © 2022 Nolde, Holtfreter, Kocher, Alayash, Reckelkamm, Ehmke, Baurecht and Baumeister.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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