Multi-Domains in a Single Lattice Formed by DNA Self-Assembly.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
02 Aug 2022
02 Aug 2022
Historique:
received:
25
04
2022
accepted:
07
07
2022
entrez:
8
8
2022
pubmed:
9
8
2022
medline:
9
8
2022
Statut:
epublish
Résumé
Using sequence programmability and the characteristics of self-assembly, DNA has been utilized in the construction of various nanostructures and the placement of specific patterns on lattices. Even though many complex structures and patterns formed by DNA assembly have been reported, the fabrication of multi-domain patterns in a single lattice has rarely been discussed. Multi-domains possessing specifically designed patterns in a single lattice provide the possibility to generate multiple patterns that enhance the pattern density in a given single lattice. Here, we introduce boundaries to construct double- and quadruple-domains with specific patterns in a single lattice and verify them with atomic force microscopy. ON, OFF, and ST (stripe) patterns on a lattice are made of DNA tiles with hairpins (ON), without hairpins (OFF), and alternating DNA tiles without and with hairpins (formed as a stripe, ST). For double- and quadruple-domain lattices, linear and cross boundaries were designed to fabricate two (e.g., ON and OFF, ON and ST, and OFF and ST) and four (OFF, ST, OFF, and ON) different types of patterns in single lattices, respectively. In double-domain lattices, each linear boundary is placed between two different domains. Similarly, four linear boundaries connected with a seed tile (i.e., a cross boundary) can separate four domains in a single lattice in quadruple-domain lattices. Due to the presence of boundaries, the pattern growth directions are different in each domain. The experimentally obtained multi-domain patterns agree well with our design. Lastly, we propose the possibility of the construction of a hexadomain lattice through the mapping from hexagonal to square grids converted by using an axial coordinate system. By proposing a hexadomain lattice design, we anticipate the possibility to extend to higher numbers of multi-domains in a single lattice, thereby further increasing the information density in a given lattice.
Identifiants
pubmed: 35936484
doi: 10.1021/acsomega.2c02556
pmc: PMC9352336
doi:
Types de publication
Journal Article
Langues
eng
Pagination
26514-26522Informations de copyright
© 2022 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
J Am Chem Soc. 2006 Dec 20;128(50):15978-9
pubmed: 17165718
Nat Commun. 2021 Mar 1;12(1):1358
pubmed: 33649304
Nano Lett. 2011 Feb 9;11(2):657-60
pubmed: 21218848
Nat Rev Genet. 2019 Aug;20(8):456-466
pubmed: 31068682
Nano Lett. 2008 Jul;8(7):1791-7
pubmed: 18162000
ACS Nano. 2020 May 26;14(5):5260-5267
pubmed: 32159938
ACS Nano. 2011 Jun 28;5(6):5175-9
pubmed: 21619064
Nanotechnology. 2019 Nov 05;31(8):085604
pubmed: 31689698
Sci Rep. 2019 Feb 19;9(1):2252
pubmed: 30783171
Nature. 2006 Mar 16;440(7082):297-302
pubmed: 16541064
Nature. 2012 May 30;485(7400):623-6
pubmed: 22660323
Chem Commun (Camb). 2011 Oct 21;47(39):11053-5
pubmed: 21897950
J Am Chem Soc. 2004 Dec 22;126(50):16344-52
pubmed: 15600335
Nano Lett. 2005 Dec;5(12):2586-92
pubmed: 16351220
J Am Chem Soc. 2005 Sep 7;127(35):12202-3
pubmed: 16131180
Biochemistry. 1993 Apr 6;32(13):3211-20
pubmed: 8461289
Genome Res. 2011 May;21(5):734-40
pubmed: 21245279
Nature. 2003 Jan 23;421(6921):427-31
pubmed: 12540916
Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15236-41
pubmed: 17881584
Science. 2012 Feb 17;335(6070):831-4
pubmed: 22344439
Angew Chem Int Ed Engl. 2009;48(37):6820-3
pubmed: 19688799
Science. 2012 Nov 30;338(6111):1177-83
pubmed: 23197527
Nanoscale. 2021 Dec 2;13(46):19376-19384
pubmed: 34812465
Nat Chem. 2016 Feb;8(2):162-70
pubmed: 26791900
Nature. 2000 Sep 28;407(6803):493-6
pubmed: 11028996
Nano Lett. 2005 Apr;5(4):729-33
pubmed: 15826117
ACS Nano. 2018 May 22;12(5):4369-4377
pubmed: 29683650
Angew Chem Int Ed Engl. 2007;46(33):6226-36
pubmed: 17640011
Nature. 1953 Apr 25;171(4356):737-8
pubmed: 13054692
Chemphyschem. 2006 Aug 11;7(8):1641-7
pubmed: 16832805
J Theor Biol. 1982 Nov 21;99(2):237-47
pubmed: 6188926
Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10665-9
pubmed: 18667705
Nature. 1998 Aug 6;394(6693):539-44
pubmed: 9707114
Science. 2008 Aug 8;321(5890):824-6
pubmed: 18687961