Targeting 17β-estradiol biosynthesis in neural stem cells improves stroke outcome.
brain repair
cell therapy
cerebral ischemia
estrogen
neuroprotection
steroidogenesis
transplantation
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2022
2022
Historique:
received:
10
04
2022
accepted:
27
06
2022
entrez:
8
8
2022
pubmed:
9
8
2022
medline:
9
8
2022
Statut:
epublish
Résumé
Dax-1 (dosage-sensitive sex reversal adrenal hypoplasia congenital region on X-chromosome gene 1) blocks 17β-estradiol biosynthesis and its knockdown would be expected to increase 17β-estradiol production. We hypothesized that knockdown of Dax-1 in a conditionally immortalized neural stem cell (NSC) line, MHP36, is a useful approach to increase 17β-estradiol production. Short hairpin (sh) RNA targeted to
Identifiants
pubmed: 35936502
doi: 10.3389/fncel.2022.917181
pmc: PMC9355602
doi:
Types de publication
Journal Article
Langues
eng
Pagination
917181Informations de copyright
Copyright © 2022 Patkar, Uwanogho, Modo, Tate, Plevin and Carswell.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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