The Plasmodium falciparum Nuclear Protein Phosphatase NIF4 Is Required for Efficient Merozoite Invasion and Regulates Artemisinin Sensitivity.
RNA polymerase II
asexual development
invasion
malaria
protein phosphatase
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
30 08 2022
30 08 2022
Historique:
pubmed:
9
8
2022
medline:
3
9
2022
entrez:
8
8
2022
Statut:
ppublish
Résumé
Artemisinin resistance in Plasmodium falciparum has been associated with a mutation in the NLI-interacting factor-like phosphatase PfNIF4, in addition to the mutations in the Kelch13 protein as the major determinant. We found that PfNIF4 was predominantly expressed at the schizont stage and localized in the nuclei of the parasite. To elucidate the functions of PfNIF4 in P. falciparum, we performed PfNIF4 knockdown (KD) using the inducible ribozyme system. PfNIF4 KD attenuated merozoite invasion and affected gametocytogenesis. PfNIF4 KD parasites also showed significantly increased
Identifiants
pubmed: 35938722
doi: 10.1128/mbio.01897-22
pmc: PMC9426563
doi:
Substances chimiques
Antimalarials
0
Artemisinins
0
Protozoan Proteins
0
artemisinin
9RMU91N5K2
RNA Polymerase II
EC 2.7.7.-
Phosphoprotein Phosphatases
EC 3.1.3.16
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0189722Subventions
Organisme : NIAID NIH HHS
ID : R01 AI128940
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI089672
Pays : United States
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