Analytical Sensitivity of Eight Different SARS-CoV-2 Antigen-Detecting Rapid Tests for Omicron-BA.1 Variant.

COVID-19 Omicron variant Omicron-BA.1 variant SARS-CoV-2 antigen-detecting rapid diagnostic tests variants of concern

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
31 08 2022
Historique:
pubmed: 9 8 2022
medline: 9 9 2022
entrez: 8 8 2022
Statut: ppublish

Résumé

The emergence of each novel SARS-CoV-2 variant of concern (VOC) requires investigation of its potential impact on the performance of diagnostic tests in use, including antigen-detecting rapid diagnostic tests (Ag-RDTs). Although anecdotal reports have been circulating that the newly emerged Omicron-BA.1 variant is in principle detectable by Ag-RDTs, few data on sensitivity are available. We have performed (i) analytical sensitivity testing with cultured virus in eight Ag-RDTs and (ii) retrospective testing in duplicates with clinical samples from vaccinated individuals with Omicron-BA.1 (

Identifiants

pubmed: 35938792
doi: 10.1128/spectrum.00853-22
pmc: PMC9430749
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0085322

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Auteurs

Meriem Bekliz (M)

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Kenneth Adea (K)

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Olha Puhach (O)

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Francisco Perez-Rodriguez (F)

Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland.

Stéfane Marques Melancia (S)

Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland.

Stephanie Baggio (S)

Division of Prison Health, Geneva University Hospitals & University of Geneva, Geneva, Switzerland.

Anna-Rita Corvaglia (AR)

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Frederique Jacquerioz (F)

Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Division of Tropical and Humanitarian Medicine, Geneva University Hospitals, Geneva, Switzerland.
Primary Care Division, Geneva University Hospitals, Geneva, Switzerland.

Catia Alvarez (C)

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Manel Essaidi-Laziosi (M)

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.

Camille Escadafal (C)

FIND, Geneva, Switzerland.

Laurent Kaiser (L)

Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, Geneva University Hospitals, Geneva, Switzerland.
Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland.

Isabella Eckerle (I)

Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Geneva Centre for Emerging Viral Diseases, Geneva University Hospitals and University of Geneva, Geneva, Switzerland.
Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland.

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Classifications MeSH