Ginseng volatile oil prolongs the lifespan and healthspan of Caenorhabditis elegans.
Antioxidant
Autophagy
Caenorhabditis elegans
Ginseng volatile oil
Hormesis
Lifespan
Journal
Biogerontology
ISSN: 1573-6768
Titre abrégé: Biogerontology
Pays: Netherlands
ID NLM: 100930043
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
14
11
2021
accepted:
03
02
2022
pubmed:
9
8
2022
medline:
23
8
2022
entrez:
8
8
2022
Statut:
ppublish
Résumé
Ginseng volatile oil (GVO) is one of the main components of ginseng and has antibacterial and anti-inflammatory properties. In this study, gas chromatography-mass spectrometry (GC-MS) was applied to characterize GVO chemical composition, and 73 volatile components were detected from GVO. Caenorhabditis elegans was used as animal model to further elucidate the antioxidant and anti-aging effects of GVO in vivo. The results suggested that GVO significantly prolonged the lifespan of C. elegans and promoted its health without damaging its reproductive capacity. In addition, GVO increased the antioxidant capacity and survival rate of nematodes after heat shock. Transcriptional sequencing showed that autophagy-related genes atg-4.2, atg-7, lgg-2, and cyd-1 were up-regulated, and superoxide dismutase 1 (sod-1) expression was increased after GVO pretreatment. Considering the role of autophagy and antioxidant in aging, the expression of autophagy substrate P62 protein in BC12921 strain was analyzed and found to decrease by more than 50.00% after treatment with GVO. In addition, the lifespan of SOD-1 mutant nematodes was not significantly different from that of the control group. SOD activity and autophagy were activated, which is a clear expression of hormesis. All these results suggest that GVO prolongs the lifespan and healthspan of C. elegans, and its biological functions may be related to hormesis.
Identifiants
pubmed: 35939242
doi: 10.1007/s10522-022-09956-z
pii: 10.1007/s10522-022-09956-z
pmc: PMC9358063
doi:
Substances chimiques
Antioxidants
0
Caenorhabditis elegans Proteins
0
LGG-2 protein, C elegans
0
Microtubule-Associated Proteins
0
Oils, Volatile
0
Superoxide Dismutase
EC 1.15.1.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
485-497Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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