DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium.
RPE
age-related macular degeneration
drusen
mTORC1
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
16 08 2022
16 08 2022
Historique:
entrez:
8
8
2022
pubmed:
9
8
2022
medline:
11
8
2022
Statut:
ppublish
Résumé
The mechanistic target of rapamycin (mTOR) is assembled into signaling complexes of mTORC1 or mTORC2, and plays key roles in cell metabolism, stress response, and nutrient and growth factor sensing. Accumulating evidence from human and animal model studies has demonstrated a pathogenic role of hyperactive mTORC1 in age-related macular degeneration (AMD). The retinal pigment epithelium (RPE) is a primary injury site in AMD. In mouse models of RPE-specific deletion of Tuberous sclerosis 1 (
Identifiants
pubmed: 35939707
doi: 10.1073/pnas.2207489119
pmc: PMC9388070
doi:
Substances chimiques
Dopamine and cAMP-Regulated Phosphoprotein 32
0
PPP1R1B protein, human
0
Ppp1r1b protein, mouse
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2207489119Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES031980
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY021725
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026999
Pays : United States
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