Cellular and Molecular Diversity in Scleroderma.

Humans Scleroderma, Systemic / genetics Proteomics / methods Gene Expression Profiling

Journal

Seminars in immunology
ISSN: 1096-3618
Titre abrégé: Semin Immunol
Pays: England
ID NLM: 9009458

Informations de publication

Date de publication:
Dec 2021
Historique:
pubmed: 9 8 2022
medline: 15 12 2022
entrez: 8 8 2022
Statut: ppublish

Résumé

With the increasing armamentarium of high-throughput tools available at manageable cost, it is attractive and informative to determine the molecular underpinnings of patient heterogeneity in systemic sclerosis (SSc). Given the highly variable clinical outcomes of patients labelled with the same diagnosis, unravelling the cellular and molecular basis of disease heterogeneity will be crucial to predicting disease risk, stratifying management and ultimately informing a patient-centered precision medicine approach. Herein, we summarise the findings of the past several years in the fields of genomics, transcriptomics, and proteomics that contribute to unraveling the cellular and molecular heterogeneity of SSc. Expansion of these findings and their routine integration with quantitative analysis of histopathology and imaging studies into clinical care promise to inform a scientifically driven patient-centred personalized medicine approach to SSc in the near future.

Identifiants

DOI: 10.1016/j.smim.2022.101648 PMID: 35940960
pubmed: 35940960
pii: S1044-5323(22)00065-3
doi: 10.1016/j.smim.2022.101648
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101648

Informations de copyright

Copyright © 2022. Published by Elsevier Ltd.

Auteurs

Monique Hinchcliff (M)

Yale School of Medicine, Department of Internal Medicine, Section of Rheumatology, Allergy & Immunology, USA. Electronic address: monique.hinchcliff@yale.edu.

Rolando Garcia-Milian (R)

Bioinformatics Support Program, Cushing/Whitney Medical Library, New Haven, CT, USA.

Stefano Di Donato (S)

Raynaud's and Scleroderma Programme, Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR Biomedical Research Centre, University of Leeds, UK.

Karin Dill (K)

Emory Healthcare, USA.

Elizabeth Bundschuh (E)

Yale School of Medicine, Department of Internal Medicine, Section of Rheumatology, Allergy & Immunology, USA.

Francesco Del Galdo (FD)

Raynaud's and Scleroderma Programme, Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR Biomedical Research Centre, University of Leeds, UK. Electronic address: F.delgaldo@leeds.ac.uk.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cellular and Molecular Diversity in Scleroderma.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Sclérodermie systémique › Cellular and Molecular Diversity in Scleroderma.
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Protéomique › Cellular and Molecular Diversity in Scleroderma.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Cellular and Molecular Diversity in Scleroderma.