Blasts in context: the impact of the immune environment on acute myeloid leukemia prognosis and treatment.
Acute myeloid leukemia
Bone marrow
Cellular therapy
Hematopoietic stem cell transplantation
Immune environment
Immunotherapy
Journal
Blood reviews
ISSN: 1532-1681
Titre abrégé: Blood Rev
Pays: England
ID NLM: 8708558
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
received:
01
04
2022
revised:
22
06
2022
accepted:
13
07
2022
pubmed:
9
8
2022
medline:
28
1
2023
entrez:
8
8
2022
Statut:
ppublish
Résumé
Acute myeloid leukemia (AML) is a cancer that originates from the bone marrow (BM). Under physiological conditions, the bone marrow supports the homeostasis of immune cells and hosts memory lymphoid cells. In this review, we summarize our present understanding of the role of the immune microenvironment on healthy bone marrow and on the development of AML, with a focus on T cells and other lymphoid cells. The types and function of different immune cells involved in the AML microenvironment as well as their putative role in the onset of disease and response to treatment are presented. We also describe how the immune context predicts the response to immunotherapy in AML and how these therapies modulate the immune status of the bone marrow. Finally, we focus on allogeneic stem cell transplantation and summarize the current understanding of the immune environment in the post-transplant bone marrow, the factors associated with immune escape and relevant strategies to prevent and treat relapse.
Identifiants
pubmed: 35941029
pii: S0268-960X(22)00065-0
doi: 10.1016/j.blre.2022.100991
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100991Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have no conflict of interest to disclose relevant for this review.