Ruxolitinib for Refractory Macrophage Activation Syndrome Complicating Adult-Onset Still's Disease.


Journal

European journal of rheumatology
ISSN: 2147-9720
Titre abrégé: Eur J Rheumatol
Pays: Turkey
ID NLM: 101656068

Informations de publication

Date de publication:
Oct 2022
Historique:
pubmed: 10 8 2022
medline: 10 8 2022
entrez: 9 8 2022
Statut: ppublish

Résumé

Macrophage activation syndrome is the most frequent life-threatening complication of adult-onset Still's disease. This is a nearly fatal case of a young patient, which has been refractory to corticoste- roids, anakinra, tocilizumab, cyclosporine A, and etoposide, but eventually responded miraculously to salvage therapy with ruxolitinib. We review recent pertinent data related to the therapeutic value of ruxolitinib for macrophage activation syndrome triggered by adult-onset Still's disease.

Identifiants

pubmed: 35943464
doi: 10.5152/eurjrheum.2022.21064
pmc: PMC10089131
doi:

Types de publication

Journal Article

Langues

eng

Pagination

217-220

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Auteurs

Ofer Levy (O)

Shamir Medical Center, Internal Medicine B, Rheumatology Unit, Zerifin, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Arie Apel (A)

Shamir Medical Center, Department of Hematology, Zerifin, Israel.

Hossam Alhdor (H)

Shamir Medical Center, Internal Medicine B, Zerifin, Israel.

Avraham Mizrachi (A)

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Shamir Medical Center, Internal Medicine B, Zerifin, Israel.

Nancy Agmon-Levin (N)

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Sheba Medical Center, Center for Autoimmune Diseases, Clinical Immunology, Angioedema and Allergy Unit, Tel-Hashomer, Israel.

Maya Koren-Michowitz (M)

Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel; Shamir Medical Center, Department of Hematology, Zerifin, Israel.

Mirit Amit-Vazina (M)

Shamir Medical Center, Internal Medicine B, Rheumatology Unit, Zerifin, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Classifications MeSH