Circulation Time-Optimized Albumin Nanoplatform for Quantitative Visualization of Lung Metastasis via Targeting of Macrophages.

Humans Mannose Blood Circulation Time Macrophages Serum Albumin Lung Neoplasms / diagnostic imaging
albumin nanoplatform blood circulation lung metastasis macrophage noninvasive imaging

Journal

ACS nano
ISSN: 1936-086X
Titre abrégé: ACS Nano
Pays: United States
ID NLM: 101313589

Informations de publication

Date de publication:
23 08 2022
Historique:
pubmed: 10 8 2022
medline: 15 11 2022
entrez: 9 8 2022
Statut: ppublish

Résumé

The development of molecular imaging probes to identify key cellular changes within lung metastases may lead to noninvasive detection of metastatic lesions in the lung. In this study, we constructed a macrophage-targeted clickable albumin nanoplatform (CAN) decorated with mannose as the targeting ligand using a click reaction to maintain the intrinsic properties of albumin

Identifiants

DOI: 10.1021/acsnano.2c03075 PMID: 35943956 PMC: PMC9413422
pubmed: 35943956
doi: 10.1021/acsnano.2c03075
pmc: PMC9413422
doi:

Substances chimiques

Mannose PHA4727WTP
Serum Albumin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

12262-12275

Auteurs

Hyewon Chung (H)

Macrophage Lab, Department of Microbiology and Immunology, and Institute of Endemic Disease, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Bio-MAX Institute, Seoul National University, Seoul 03080, Republic of Korea.

Ji Yong Park (JY)

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Cancer Research Institute, Seoul National University, Seoul 03080, Republic of Korea.
Dental Research Institute, Seoul National University, Seoul 03080, Republic of Korea.

Kyuwan Kim (K)

Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Cancer Research Institute, Seoul National University, Seoul 03080, Republic of Korea.

Ran Ji Yoo (RJ)

Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Cancer Research Institute, Seoul National University, Seoul 03080, Republic of Korea.

Minseok Suh (M)

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea.

Gyo Jeong Gu (GJ)

Macrophage Lab, Department of Microbiology and Immunology, and Institute of Endemic Disease, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
ORCID: 0000-0003-0521-4270

Jin Sil Kim (JS)

Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Tae Hyeon Choi (TH)

Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea.

Jung Woo Byun (JW)

Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Young Wook Ju (YW)

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Wonshik Han (W)

Department of Surgery and Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Han Suk Ryu (HS)

Department of Pathology, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Gehoon Chung (G)

Dental Research Institute, Seoul National University, Seoul 03080, Republic of Korea.
Department of Oral Physiology, Seoul National University, School of Dentistry, Seoul 03080, Republic of Korea.

Do Won Hwang (DW)

Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Research and Development Center, THERABEST, Co. Ltd., Seoul 03080, Republic of Korea.

Yujin Kim (Y)

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Hye-Ryun Kang (HR)

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

Yi Rang Na (YR)

Transdisciplinary Department of Medicine and Advanced Technology, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Hongyoon Choi (H)

Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.

Hyung-Jun Im (HJ)

Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, Seoul National University, Seoul 03080, Republic of Korea.
Research Institute for Convergence Science, Seoul National University, Seoul 08823, Republic of Korea.
ORCID: 0000-0002-4368-6685

Yun-Sang Lee (YS)

Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Department of Nuclear Medicine, Seoul National University Hospital, Seoul 03080, Republic of Korea.
Cancer Research Institute, Seoul National University, Seoul 03080, Republic of Korea.

Seung Hyeok Seok (SH)

Macrophage Lab, Department of Microbiology and Immunology, and Institute of Endemic Disease, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.
ORCID: 0000-0002-4315-0688

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Circulation Time-Optimized Albumin...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Mannose › Circulation Time-Optimized Albumin...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic cardiovasculaire › Temps de circulation sanguine › Circulation Time-Optimized Albumin...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Circulation Time-Optimized Albumin...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du sang › Sérumalbumine › Circulation Time-Optimized Albumin...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Tumeurs de l'appareil respiratoire › Tumeurs du poumon › Circulation Time-Optimized Albumin...