Effect of Single-dose Azithromycin on Pneumococcal Carriage and Resistance: A Randomized Controlled Trial.
Journal
The Pediatric infectious disease journal
ISSN: 1532-0987
Titre abrégé: Pediatr Infect Dis J
Pays: United States
ID NLM: 8701858
Informations de publication
Date de publication:
01 09 2022
01 09 2022
Historique:
entrez:
9
8
2022
pubmed:
10
8
2022
medline:
12
8
2022
Statut:
ppublish
Résumé
We evaluated antibiotic resistance selection in Streptococcus pneumoniae isolates from children participating in an individually randomized trial of single-dose azithromycin versus placebo. After 14 days, the prevalence of resistance to erythromycin, oxacillin, and clindamycin was elevated in the azithromycin versus placebo group. There was no difference at 6 months.
Identifiants
pubmed: 35944061
doi: 10.1097/INF.0000000000003585
pii: 00006454-202209000-00011
pmc: PMC9359759
doi:
Substances chimiques
Anti-Bacterial Agents
0
Clindamycin
3U02EL437C
Azithromycin
83905-01-5
Banques de données
ClinicalTrials.gov
['NCT03676751']
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
728-730Informations de copyright
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to disclose.
Références
Keenan JD, Bailey RL, West SK, et al.; MORDOR Study Group. Azithromycin to reduce childhood mortality in Sub-Saharan Africa. N Engl J Med. 2018;378:1583–1592.
O’Brien K, Emerson P, Hooper PJ, et al. Antimicrobial resistance following mass azithromycin distribution for trachoma: a systematic review. Lancet Infect Dis. 2019;19:e14–e25.
Doan T, Worden L, Hinterwirth A, et al. Macrolide and nonmacrolide resistance with mass azithromycin distribution. N Engl J Med. 2020;383:1941–1950.
Sie A, Coulibaly B, Adama S, et al. Antibiotic prescriptions among children under age 5 in Nouna district, Burkina Faso. Am J Trop Med Hyg. 2019;100:1121–1124.
Coulibaly B, Sié A, Dah C, et al. Effect of a single dose of oral azithromycin on malaria parasitaemia in children: a randomized controlled trial. Malar J. 2021;20:360.
Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard—Twelfth Edition. 2015.
Syrogiannopoulos GA, Grivea IN, Ednie LM, et al. Antimicrobial susceptibility and macrolide resistance inducibility of Streptococcus pneumoniae carrying erm(A), erm(B), or mef(A). Antimicrob Agents Chemother. 2003;47:2699–2702.
Samore MH, Lipsitch M, Alder SC, et al. Mechanisms by which antibiotics promote dissemination of resistant pneumococci in human populations. Am J Epidemiol. 2006;163:160–170.
Arzika AM, Maliki R, Abdou A, et al. Gut resistome of preschool children after prolonged mass azithromycin distribution: a cluster-randomized trial. Clin Infect Dis. 2021;73:1292–1295.
Lipsitch M. Measuring and interpreting associations between antibiotic use and penicillin resistance in Streptococcus pneumoniae. Clin Infect Dis. 2001;32:1044–1054.