Covalent Proteomimetic Inhibitor of the Bacterial FtsQB Divisome Complex.
Journal
Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056
Informations de publication
Date de publication:
24 08 2022
24 08 2022
Historique:
pubmed:
10
8
2022
medline:
26
8
2022
entrez:
9
8
2022
Statut:
ppublish
Résumé
The use of antibiotics is threatened by the emergence and spread of multidrug-resistant strains of bacteria. Thus, there is a need to develop antibiotics that address new targets. In this respect, the bacterial divisome, a multi-protein complex central to cell division, represents a potentially attractive target. Of particular interest is the FtsQB subcomplex that plays a decisive role in divisome assembly and peptidoglycan biogenesis in
Identifiants
pubmed: 35945166
doi: 10.1021/jacs.2c06304
pmc: PMC9413201
doi:
Substances chimiques
Anti-Bacterial Agents
0
Bacterial Proteins
0
Cell Cycle Proteins
0
Escherichia coli Proteins
0
Membrane Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
15303-15313Références
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