Re-emerging threat of Trypanosoma cruzi vector transmission in El Salvador, update from 2018 to 2020.
Chagas disease
Triatoma dimidiata
Triatomine
Trypanosoma cruzi
Vector transmission
Journal
Infectious diseases of poverty
ISSN: 2049-9957
Titre abrégé: Infect Dis Poverty
Pays: England
ID NLM: 101606645
Informations de publication
Date de publication:
09 Aug 2022
09 Aug 2022
Historique:
received:
26
11
2021
accepted:
13
07
2022
entrez:
9
8
2022
pubmed:
10
8
2022
medline:
12
8
2022
Statut:
epublish
Résumé
Since the late twentieth century, Chagas disease gained global attention to suppress the vector burden as a main control strategy in endemic countries. In Central America, multi-national initiative successfully achieved significant reduction in the estimated disease prevalence as well as elimination of the region's principal vector species at the time in 2012. While the last decade has witnessed significant changes in ecosystem-such as urbanization and replacement of the main vector species-that can possibly affect the vector's habitation and residual transmission, the up-to-date vector burden in the region has not been evaluated thoroughly due to the cessation of active vector surveillance. The aim of this study was to update the risk of vector-borne Trypanosoma cruzi infection in El Salvador, the top Chagas disease-endemic country in Central America. A nationwide vector survey was conducted in the domestic environment of El Salvador from September 2018 to November 2020. The selection of the houses for inspection was based on expert purposeful sampling. Infection for T. cruzi was examined by microscopic observation of the insects' feces, followed by a species confirmation using PCR. The data were analyzed using R software version 4.1.3. Proportion estimates with 95% confidence intervals were inferred using the Jeffrey's method provided under the epiR package. A total of 1529 Triatoma dimidiata was captured from 107 houses (infestation rate, 34.4%; 107/311) in all the fourteen departments of the country visited within the period; prevalence of T. cruzi infection was as high as 10% (153/1529). In the country, domestic T. dimidiata infestation was distributed ubiquitously, while T. cruzi infection rates varied across the departments. Five out of fourteen departments showed higher infection rates than the average, suggesting sporadic high-risk areas in the country. Our comprehensive study revealed substantial T. cruzi infection of T. dimidiata across the country, indicating potential active transmission of the disease. Therefore, strengthened surveillance for both vector and human infection is required to truly eliminate the risk of T. cruzi transmission in Central America.
Sections du résumé
BACKGROUND
BACKGROUND
Since the late twentieth century, Chagas disease gained global attention to suppress the vector burden as a main control strategy in endemic countries. In Central America, multi-national initiative successfully achieved significant reduction in the estimated disease prevalence as well as elimination of the region's principal vector species at the time in 2012. While the last decade has witnessed significant changes in ecosystem-such as urbanization and replacement of the main vector species-that can possibly affect the vector's habitation and residual transmission, the up-to-date vector burden in the region has not been evaluated thoroughly due to the cessation of active vector surveillance. The aim of this study was to update the risk of vector-borne Trypanosoma cruzi infection in El Salvador, the top Chagas disease-endemic country in Central America.
METHODS
METHODS
A nationwide vector survey was conducted in the domestic environment of El Salvador from September 2018 to November 2020. The selection of the houses for inspection was based on expert purposeful sampling. Infection for T. cruzi was examined by microscopic observation of the insects' feces, followed by a species confirmation using PCR. The data were analyzed using R software version 4.1.3. Proportion estimates with 95% confidence intervals were inferred using the Jeffrey's method provided under the epiR package.
RESULTS
RESULTS
A total of 1529 Triatoma dimidiata was captured from 107 houses (infestation rate, 34.4%; 107/311) in all the fourteen departments of the country visited within the period; prevalence of T. cruzi infection was as high as 10% (153/1529). In the country, domestic T. dimidiata infestation was distributed ubiquitously, while T. cruzi infection rates varied across the departments. Five out of fourteen departments showed higher infection rates than the average, suggesting sporadic high-risk areas in the country.
CONCLUSIONS
CONCLUSIONS
Our comprehensive study revealed substantial T. cruzi infection of T. dimidiata across the country, indicating potential active transmission of the disease. Therefore, strengthened surveillance for both vector and human infection is required to truly eliminate the risk of T. cruzi transmission in Central America.
Identifiants
pubmed: 35945552
doi: 10.1186/s40249-022-01008-5
pii: 10.1186/s40249-022-01008-5
pmc: PMC9361614
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
89Subventions
Organisme : Science and Technology Research Partnership for Sustainable Development
ID : JP 21jm0110016
Informations de copyright
© 2022. The Author(s).
Références
Clin Infect Dis. 2009 Sep 1;49(5):e52-4
pubmed: 19640226
Diagn Microbiol Infect Dis. 2017 Jul;88(3):225-232
pubmed: 28456430
Infect Dis Poverty. 2021 Sep 15;10(1):117
pubmed: 34526137
Mol Biochem Parasitol. 1989 Mar 15;33(3):205-14
pubmed: 2565018
Wkly Epidemiol Rec. 2015 Feb 6;90(6):33-43
pubmed: 25671846
Parasit Vectors. 2012 Feb 22;5:45
pubmed: 22357219
Mem Inst Oswaldo Cruz. 2002 Jul;97(5):603-12
pubmed: 12219120
Vector Borne Zoonotic Dis. 2007 Winter;7(4):597-606
pubmed: 17979537
Mem Inst Oswaldo Cruz. 2014 Apr;109(2):256-8
pubmed: 24676660
Acta Trop. 2010 Jul-Aug;115(1-2):14-21
pubmed: 19932071
Am J Trop Med Hyg. 2015 Jul;93(1):97-107
pubmed: 25870430
J Infect Dev Ctries. 2014 Aug 13;8(8):1029-36
pubmed: 25116670
Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1:17-30
pubmed: 19753454