Persistent neuroinflammation and behavioural deficits after single mild traumatic brain injury.
Mild traumatic brain injury
TSPO microPET imaging
molecular MRI
neuroinflammation
persisting behavioural deficits
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
pubmed:
11
8
2022
medline:
19
11
2022
entrez:
10
8
2022
Statut:
ppublish
Résumé
Despite an apparently silent imaging, some patients with mild traumatic brain injury (TBI) experience cognitive dysfunctions, which may persist chronically. Brain changes responsible for these dysfunctions are unclear and commonly overlooked. It is thus crucial to increase our understanding of the mechanisms linking the initial event to the functional deficits, and to provide objective evidence of brain tissue alterations underpinning these deficits. We first set up a murine model of closed-head controlled cortical impact, which provoked persistent cognitive and sensorimotor deficits, despite no evidence of brain contusion or bleeding on MRI, thus recapitulating features of mild TBI. Molecular MRI for P-selectin, a key adhesion molecule, detected no sign of cerebrovascular inflammation after mild TBI, as confirmed by immunostainings. By contrast,
Identifiants
pubmed: 35945692
doi: 10.1177/0271678X221119288
pmc: PMC9670002
doi:
Substances chimiques
Receptors, GABA
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2216-2229Références
J Nucl Med. 2011 Aug;52(8):1235-9
pubmed: 21764792
Front Aging Neurosci. 2022 Mar 31;14:868448
pubmed: 35431903
J Neurotrauma. 2020 Jun 1;37(11):1342-1357
pubmed: 31830858
Ann Neurol. 2011 Sep;70(3):374-83
pubmed: 21710619
Brain. 2018 Sep 1;141(9):2685-2699
pubmed: 30084913
Neuroscience. 2017 Jul 25;356:52-63
pubmed: 28527955
J Neuroimmunol. 2019 Jul 15;332:112-125
pubmed: 31005712
Cell Transplant. 2017 Jul;26(7):1131-1155
pubmed: 28933213
Neurology. 2018 Oct 9;91(15):e1385-e1389
pubmed: 30209234
Future Neurol. 2012 May 1;7(3):329-339
pubmed: 23539500
Neuroscience. 2012 Dec 6;225:65-75
pubmed: 22960311
Mult Scler. 2018 Apr;24(4):543-545
pubmed: 28443358
Cell. 2020 Mar 5;180(5):833-846.e16
pubmed: 32142677
PLoS One. 2017 Mar 29;12(3):e0173798
pubmed: 28355230
J Labelled Comp Radiopharm. 2015 Jan;58(1):1-6
pubmed: 25616229
J Clin Med. 2019 Jul 30;8(8):
pubmed: 31366109
JAMA Psychiatry. 2019 Mar 1;76(3):249-258
pubmed: 30698636
Neuroimage. 2007 Oct 15;38(1):34-42
pubmed: 17707126
J Neurotrauma. 2019 Mar 1;36(5):768-788
pubmed: 30032713
Exp Neurol. 2016 Jan;275 Pt 3:367-380
pubmed: 26112314
Neurobiol Aging. 2015 Apr;36(4):1639-1652
pubmed: 25680265
Sci Rep. 2020 Jul 20;10(1):11991
pubmed: 32686718
Lancet. 1974 Jul 13;2(7872):81-4
pubmed: 4136544
J Pharmacol Sci. 2019 May;140(1):106-108
pubmed: 31133404
J Cereb Blood Flow Metab. 2020 Sep;40(9):1769-1777
pubmed: 32663096
Nature. 2014 Jan 9;505(7482):223-8
pubmed: 24317693
Acta Neuropathol. 2000 Sep;100(3):313-22
pubmed: 10965802
Front Mol Neurosci. 2019 Nov 26;12:284
pubmed: 32038157
Exp Neurol. 2007 Sep;207(1):118-27
pubmed: 17658516
Pharmacol Ther. 2019 Feb;194:44-58
pubmed: 30189290
J Cereb Blood Flow Metab. 2013 Jun;33(6):834-45
pubmed: 23443171
Mol Cell Neurosci. 2015 May;66(Pt B):75-80
pubmed: 25748121
Brain. 2017 Jan;140(1):146-157
pubmed: 28031221
Theranostics. 2018 Apr 3;8(10):2603-2620
pubmed: 29774062
Exp Neurol. 2016 Jan;275 Pt 3:316-327
pubmed: 26342753
Stroke. 2013 Jul;44(7):1988-96
pubmed: 23743972
Neuroimaging Clin N Am. 2018 Feb;28(1):67-82
pubmed: 29157854
Neuromolecular Med. 2016 Jun;18(2):158-69
pubmed: 26969181
Lancet Neurol. 2017 Dec;16(12):987-1048
pubmed: 29122524
J Neurosci. 2020 Apr 1;40(14):2960-2974
pubmed: 32094203
Sci Rep. 2020 Sep 30;10(1):16179
pubmed: 32999392
Theranostics. 2018 Feb 2;8(5):1195-1212
pubmed: 29507614
J Neurosci. 2012 Sep 12;32(37):12726-34
pubmed: 22972996
Glia. 2017 Dec;65(12):1961-1975
pubmed: 28850711
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):6116-6121
pubmed: 28533365
J Neuroinflammation. 2017 Aug 23;14(1):167
pubmed: 28835272
J Neurotrauma. 2007 Apr;24(4):657-73
pubmed: 17439349
Transl Neurodegener. 2017 Jul 11;6:20
pubmed: 28702179
Neurobiol Dis. 2015 Feb;74:58-65
pubmed: 25447235
JAMA. 2018 Aug 14;320(6):580-588
pubmed: 30120477
Eur J Pharmacol. 2003 Feb 28;463(1-3):3-33
pubmed: 12600700
Neuron. 2017 Sep 13;95(6):1246-1265
pubmed: 28910616
J Neurosurg. 2016 Feb;124(2):511-26
pubmed: 26315003
ASN Neuro. 2020 Jan-Dec;12:1759091420911770
pubmed: 32146827
J Neurosci. 2021 Feb 17;41(7):1597-1616
pubmed: 33452227
J Neuroinflammation. 2016 Jun 07;13(1):140
pubmed: 27266706
Brain. 2018 Sep 1;141(9):2740-2754
pubmed: 30052812