Adipose-Renal Axis in Diabetic Nephropathy.
Diabetic nephropathy (DN)
adipokines
adiponectin
adipose tissues
diabetes
kidney
Journal
Current medicinal chemistry
ISSN: 1875-533X
Titre abrégé: Curr Med Chem
Pays: United Arab Emirates
ID NLM: 9440157
Informations de publication
Date de publication:
2023
2023
Historique:
received:
28
01
2022
revised:
01
04
2022
accepted:
16
05
2022
pubmed:
11
8
2022
medline:
17
3
2023
entrez:
10
8
2022
Statut:
ppublish
Résumé
Long-term diabetes can lead to renal injury known as diabetic nephropathy (DN), which is a major cause of end-stage renal disease (ESRD). However, its pathogenesis has not been well explained. Adipose tissue is recognized as an important energy storage device for the body. Interestingly, many studies have shown that adipose tissue can also act as an endocrine organ by secreting a variety of adipokines to maintain homeostasis. Here, we summarize some of the adipokines that have been identified so far to, more specifically, emphasize their role in DN progression and propose that the "adipose-renal axis" may be a potential target for treating DN.
Identifiants
pubmed: 35946097
pii: CMC-EPUB-125383
doi: 10.2174/0929867329666220806115518
doi:
Substances chimiques
Adipokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1860-1874Informations de copyright
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