Ion channel model reduction using manifold boundaries.
electrophysiology
identifiability
ion channel
mathematical model
model reduction
Journal
Journal of the Royal Society, Interface
ISSN: 1742-5662
Titre abrégé: J R Soc Interface
Pays: England
ID NLM: 101217269
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
entrez:
10
8
2022
pubmed:
11
8
2022
medline:
12
8
2022
Statut:
ppublish
Résumé
Mathematical models of voltage-gated ion channels are used in basic research, industrial and clinical settings. These models range in complexity, but typically contain numerous variables representing the proportion of channels in a given state, and parameters describing the voltage-dependent rates of transition between states. An open problem is selecting the appropriate degree of complexity and structure for an ion channel model given data availability. Here, we simplify a model of the cardiac human Ether-à-go-go related gene (hERG) potassium ion channel, which carries cardiac
Identifiants
pubmed: 35946166
doi: 10.1098/rsif.2022.0193
pmc: PMC9363999
doi:
Substances chimiques
ERG1 Potassium Channel
0
Ether-A-Go-Go Potassium Channels
0
Ion Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20220193Subventions
Organisme : Wellcome Trust
ID : 212203/Z/18/Z
Pays : United Kingdom
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