Mechanisms of ultraviolet-induced melasma formation: A review.
emerging therapies
gene regulation
melasma
skin barrier
ultraviolet radiation
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
03
07
2022
received:
15
05
2022
accepted:
26
07
2022
pubmed:
11
8
2022
medline:
7
12
2022
entrez:
10
8
2022
Statut:
ppublish
Résumé
Melasma, a pigmentation disorder, commonly occurs in exposed skin areas and can be attributed to several factors. Ultraviolet radiation (UVR) is the primary factor that induces and aggravates melasma. Considering gene expression, exposed skin areas experience abnormal gene expression, involving melanin metabolism, oxidative stress, impaired skin barrier function, and abnormal composition of nerve factors. From a histological perspective, UVR can cause basement membrane collapse, melanocyte sinking, and disorders of skin lipid metabolism. Emerging therapies have focused on these pathological alterations in melasma, including platelet-rich plasma, mesotherapy, and phytochemicals. Understanding the role of UVR in the development of melasma can facilitate early prevention and highlight the future direction of melasma treatment.
Identifiants
pubmed: 35946331
doi: 10.1111/1346-8138.16542
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1201-1210Subventions
Organisme : The New Xiangya Talent Projects of the Third Xiangya Hospital of Central South University
ID : 20170309
Informations de copyright
© 2022 Japanese Dermatological Association.
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