Clinical history analysis of Japanese melanoma cases and characteristics of melanoma with childhood onset.
BRAF
congenial melanocytic nevus
nevus-associated melanoma
Journal
The Journal of dermatology
ISSN: 1346-8138
Titre abrégé: J Dermatol
Pays: England
ID NLM: 7600545
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
revised:
13
07
2022
received:
20
12
2021
accepted:
27
07
2022
pubmed:
11
8
2022
medline:
7
12
2022
entrez:
10
8
2022
Statut:
ppublish
Résumé
It remains debatable whether melanoma with a clinical history of early childhood onset truly arises from a nevus. To clarify the clinical and genetic characteristics of melanoma detected at birth or several years afterwards, 249 melanoma cases seen at Shinshu University Hospital between 2006 and 2015 were retrospectively analyzed. Ten (4.0%) cases (median age 39.5 years, range 19-70 years; male/female 2/8; lesion site, 6 extremities, 2 trunk, 1 head, 1 face; cumulative sun damage [CSD] skin, 9 low-CSD, 1 high-CSD; detection at birth 3) had recorded early childhood onset. Median Breslow's tumor thickness in those cases was 6.0 mm (range: 0.4-17.5 mm). The frequency of lesions detected at <20 years of age was significantly higher for low-CSD melanoma (17.5%) than for high-CSD (3.3%) and acral (0.8%) melanoma. Although melanoma with a history of early childhood onset is rare, the characteristics of such cases should be established since most have progressed to an advanced stage at the initial visit.
Identifiants
pubmed: 35946357
doi: 10.1111/1346-8138.16545
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1334-1337Subventions
Organisme : Princess Takamatsu Cancer Research Fund
Informations de copyright
© 2022 Japanese Dermatological Association.
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