Combination effects of mesenchymal stem cells transplantation and anodal transcranial direct current stimulation on a cuprizone-induced mouse model of multiple sclerosis.
Cuprizone
Demyelination
Mesenchymal stem cell
Transcranial direct current stimulation
Journal
Journal of molecular histology
ISSN: 1567-2387
Titre abrégé: J Mol Histol
Pays: Netherlands
ID NLM: 101193653
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
27
01
2022
accepted:
20
07
2022
pubmed:
11
8
2022
medline:
14
9
2022
entrez:
10
8
2022
Statut:
ppublish
Résumé
Multiple sclerosis (MS) has no absolute treatment, and researchers are still exploring to introduce promising therapy for MS. Transcranial direct current stimulation (tDCS), is a safe, non-invasive procedure for brain stimulating which can enhance working memory, cognitive neurohabitation and motor recovery. Here, we evaluated the effects of tDCS treatment and Mesenchymal stem cells (MSCs) transplantation on remyelination ability of a Cuprizone (CPZ)-induced demyelination mouse model. tDCS significantly increased the motor coordination and balance abilities in CPZ + tDCS and CPZ + tDCS + MSCs mice in comparison to the CPZ mice. Luxol fast blue (LFB) staining showed that tDCS and MSCs transplantation could increase remyelination capacity in CPZ + tDCS and CPZ + MSCs mice compared to the CPZ mice. But, the effect of tDCS with MSCs transplantation on remyelination process was larger than each of treatment alone. Immunofluorescence technique indicated that the numbers of Olig2
Identifiants
pubmed: 35947228
doi: 10.1007/s10735-022-10092-8
pii: 10.1007/s10735-022-10092-8
doi:
Substances chimiques
Cuprizone
5N16U7E0AO
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
817-831Subventions
Organisme : Baqyiatallah University of Medical Sciences
ID : Grant No. 98000512
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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