Autophagy-mediated NCOR1 degradation is required for brown fat maturation and thermogenesis.
Autophagy
brown adipose tissue
metabolism
obesity
thermogenesis
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
pubmed:
11
8
2022
medline:
3
3
2023
entrez:
10
8
2022
Statut:
ppublish
Résumé
Brown adipose tissue (BAT) thermogenesis affects energy balance, and thereby it has the potential to induce weight loss and to prevent obesity. Here, we document a macroautophagic/autophagic-dependent mechanism of peroxisome proliferator-activated receptor gamma (PPARG) activity regulation that induces brown adipose differentiation and thermogenesis and that is mediated by TP53INP2. Disruption of TP53INP2-dependent autophagy reduced brown adipogenesis in cultured cells.
Identifiants
pubmed: 35947488
doi: 10.1080/15548627.2022.2111081
pmc: PMC9980505
doi:
Substances chimiques
PPAR gamma
0
TP53INP2 protein, human
0
Nuclear Proteins
0
NCOR1 protein, human
0
Nuclear Receptor Co-Repressor 1
0
Ncor1 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
904-925Subventions
Organisme : Medical Research Council
ID : MC_UU_12012/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0802051
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400192
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/7/33636
Pays : United Kingdom
Organisme : British Heart Foundation
ID : PG/12/53/29714
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/2
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
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