When the levee of sympathetic outflow breaks.

Humans Hypertension / metabolism Neurons / physiology Sympathetic Nervous System / metabolism

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
09 08 2022
Historique:
entrez: 10 8 2022
pubmed: 11 8 2022
medline: 13 8 2022
Statut: ppublish

Résumé

In this issue of Immunity, Bi et al. identify a microglia-neuron signaling axis that is critical for maintaining central control of the sympathetic nervous system. They find that platelet growth factor B released by microglia acts on neurons via PDGFRα to regulate sympathetic outflow. Disrupting this pathway leads to neuronal excitability, highlighting a promising therapeutic target to modulate sympathetic outflow and reduce hypertension.

Identifiants

DOI: 10.1016/j.immuni.2022.07.009 PMID: 35947976
pubmed: 35947976
pii: S1074-7613(22)00343-0
doi: 10.1016/j.immuni.2022.07.009
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

1334-1336

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors report no competing interests.

Auteurs

Austin Ferro (A)

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.

Lucas Cheadle (L)

Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address: cheadle@cshl.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › When the levee of sympathetic outflow breaks.
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › When the levee of sympathetic outflow breaks.
questionsmedicales.fr › Cellules › Neurones › When the levee of sympathetic outflow breaks.
questionsmedicales.fr › Système nerveux › Système nerveux périphérique › Système nerveux autonome › Système nerveux sympathique › When the levee of sympathetic outflow breaks.