Air pollution as an early determinant of COPD.


Journal

European respiratory review : an official journal of the European Respiratory Society
ISSN: 1600-0617
Titre abrégé: Eur Respir Rev
Pays: England
ID NLM: 9111391

Informations de publication

Date de publication:
30 Sep 2022
Historique:
received: 01 04 2022
accepted: 09 06 2022
entrez: 10 8 2022
pubmed: 11 8 2022
medline: 13 8 2022
Statut: epublish

Résumé

COPD is a progressive and debilitating disease often diagnosed after 50 years of age, but more recent evidence suggests that its onset could originate very early on in life. In this context, exposure to air pollution appears to be a potential contributor. Although the potential role of air pollution as an early determinant of COPD is emerging, knowledge gaps still remain, including an accurate qualification of air pollutants (number of pollutants quantified and exact composition) or the "one exposure-one disease" concept, which might limit the current understanding. To fill these gaps, improvements in the field are needed, such as the use of atmosphere simulation chambers able to realistically reproduce the complexity of air pollution, consideration of the exposome, as well as improving exchanges between paediatricians and adult lung specialists to take advantage of reciprocal expertise. This review should lead to a better understanding of the current knowledge on air pollution as an early determinant of COPD, as well as identify the existing knowledge gaps and opportunities to fill them. Hopefully, this will lead to better prevention strategies to scale down the development of COPD in future generations.

Identifiants

pubmed: 35948393
pii: 31/165/220059
doi: 10.1183/16000617.0059-2022
pmc: PMC9724895
pii:
doi:

Substances chimiques

Air Pollutants 0
Particulate Matter 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright ©The authors 2022.

Déclaration de conflit d'intérêts

Conflict of interest: None of the authors have any conflict of interest to declare.

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Auteurs

Zhuyi Lu (Z)

Univ Paris Est Creteil, INSERM, IMRB, Creteil, France.

Patrice Coll (P)

Université Paris Cité and Univ Paris Est Créteil, CNRS, LISA, Paris, France.

Bernard Maitre (B)

Univ Paris Est Creteil, INSERM, IMRB, Creteil, France.
Dept of Pneumology, Centre Hospitalier Intercommunal de Créteil, Créteil, France.

Ralph Epaud (R)

Univ Paris Est Creteil, INSERM, IMRB, Creteil, France.
Dept of General Pediatrics, Centre Hospitalier Intercommunal de Créteil, Créteil, France.

Sophie Lanone (S)

Univ Paris Est Creteil, INSERM, IMRB, Creteil, France sophie.lanone@inserm.fr.

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