A cross-sectional study assessing the relationship between non-alcoholic fatty liver disease and periodontal disease.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 08 2022
10 08 2022
Historique:
received:
28
03
2022
accepted:
02
08
2022
entrez:
10
8
2022
pubmed:
11
8
2022
medline:
13
8
2022
Statut:
epublish
Résumé
The risk factors for non-alcoholic fatty liver disease (NAFLD) progression are not completely known. Porphyromonas gingivalis infection is a risk factor for systemic diseases. We investigated the association of P. gingivalis infection with the risk of non-alcoholic steatohepatitis progression. Here, hematological tests, periodontal examination, and saliva collection were performed for 164 patients with NAFLD. P. gingivalis was identified in saliva using polymerase chain reaction. Hepatic steatosis and stiffness were evaluated using vibration-controlled transient elastography (VCTE) and magnetic resonance imaging. In patients with NAFLD, P. gingivalis positivity (P. gingivalis ratio ≥ 0.01%) in saliva correlated with liver stiffness determined using magnetic resonance elastography (MRE; p < 0.0001). A P. gingivalis ratio of 0.01% corresponds to 100,000 cells/mL and indicates the proportion of P. gingivalis in the total number of bacteria in the oral cavity. Patients with NAFLD and advanced fibrosis on MRE showed significantly elevated endotoxin activity; those who had > 10 periodontal pockets with depths ≥ 4 mm had significantly increased hepatic stiffness on both VCTE and MRE.
Identifiants
pubmed: 35948584
doi: 10.1038/s41598-022-17917-2
pii: 10.1038/s41598-022-17917-2
pmc: PMC9365789
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
13621Informations de copyright
© 2022. The Author(s).
Références
J Gastroenterol. 2012 May;47(5):586-95
pubmed: 22328022
J Periodontol. 2003 Dec;74(12):1736-1740
pubmed: 29539079
mSphere. 2018 Oct 17;3(5):
pubmed: 30333180
J Periodontol. 2001 Sep;72(9):1221-7
pubmed: 11577954
Clin Exp Dent Res. 2016 Sep 28;2(3):216-225
pubmed: 29744170
J Periodontal Res. 2011 Aug;46(4):497-504
pubmed: 21488875
J Clin Lipidol. 2015 Jul-Aug;9(4):576-82
pubmed: 26228676
FEMS Microbiol Lett. 2007 Jul;272(1):106-13
pubmed: 17459112
Gut. 2010 Oct;59(10):1410-5
pubmed: 20660697
Hepatology. 2009 Dec;50(6):2048-9; author reply 2049-50
pubmed: 19937689
J Dent Res. 2017 Jul;96(7):768-773
pubmed: 28363032
J Clin Periodontol. 1998 Feb;25(2):134-44
pubmed: 9495612
Sci Rep. 2020 Mar 5;10(1):4134
pubmed: 32139740
J Periodontol. 2009 Jun;80(6):901-6
pubmed: 19485819
Hepatology. 2016 Jul;64(1):73-84
pubmed: 26707365
Aliment Pharmacol Ther. 2001 Oct;15(10):1667-72
pubmed: 11564008
Am J Med. 2003 Nov;115(7):554-9
pubmed: 14599635
Diabetologia. 2012 Apr;55(4):885-904
pubmed: 22278337
J Gastroenterol. 2008;43(9):720-8
pubmed: 18807134
Front Immunol. 2021 Oct 11;12:766170
pubmed: 34707622
Aliment Pharmacol Ther. 2012 Jan;35(1):66-75
pubmed: 22050199
Hepatology. 2010 Jul;52(1):79-104
pubmed: 20578268
Horm Mol Biol Clin Investig. 2018 Oct 26;41(1):
pubmed: 30367792
Aliment Pharmacol Ther. 2012 Jul;36(1):22-9
pubmed: 22554256
J Hepatol. 2011 Dec;55(6):1383-90
pubmed: 21703200
Clin Microbiol Infect. 2007 Oct;13 Suppl 4:3-10
pubmed: 17716290
Diabet Med. 2005 Sep;22(9):1141-5
pubmed: 16108839
J Periodontol. 2007 Oct;78(10):1999-2006
pubmed: 17916001
Am J Gastroenterol. 2005 May;100(5):1072-81
pubmed: 15842581
J Hepatol. 2018 Feb;68(2):335-352
pubmed: 29122390
J Magn Reson Imaging. 2009 Jun;29(6):1332-9
pubmed: 19472390
Nat Commun. 2018 Feb 16;9(1):701
pubmed: 29453398
J Clin Periodontol. 2018 Feb;45(2):138-149
pubmed: 29280174
J Gastroenterol. 2013 Nov;48(11):1259-70
pubmed: 23307045
N Engl J Med. 2010 May 6;362(18):1675-85
pubmed: 20427778
J Periodontol. 1996 Oct;67(10 Suppl):1085-93
pubmed: 8910827
BMC Gastroenterol. 2012 Feb 16;12:16
pubmed: 22340817
Eur J Gastroenterol Hepatol. 2017 Dec;29(12):1380-1384
pubmed: 28914694
Hepatology. 2011 Nov;54(5):1610-9
pubmed: 21748765
J Hepatol. 2014 May;60(5):1026-31
pubmed: 24378529
PLoS One. 2015 Aug 31;10(8):e0137249
pubmed: 26322971
Mol Oral Microbiol. 2010 Oct;25(5):305-16
pubmed: 20883220
Aliment Pharmacol Ther. 2011 Aug;34(3):274-85
pubmed: 21623852
Gastroenterology. 2005 Jun;128(7):1898-906
pubmed: 15940625
Mol Oral Microbiol. 2010 Aug;25(4):252-9
pubmed: 20618699
J Gastroenterol Hepatol. 2014;29(7):1470-6
pubmed: 24548002
World J Gastroenterol. 2017 Dec 21;23(47):8263-8276
pubmed: 29307986
Ann Periodontol. 2002 Dec;7(1):102-11
pubmed: 16013223
Gut. 2007 Sep;56(9):1330-1
pubmed: 17470477
J Clin Periodontol. 2012 May;39(5):417-24
pubmed: 22304677
J Clin Periodontol. 1989 Oct;16(9):588-92
pubmed: 2794094
Aliment Pharmacol Ther. 2008 Jul;28(1):51-61
pubmed: 18410556
Ultrasound Med Biol. 2010 Nov;36(11):1825-35
pubmed: 20870345
Periodontol 2000. 2016 Oct;72(1):54-75
pubmed: 27501491
Gastroenterology. 2016 Mar;150(3):626-637.e7
pubmed: 26677985