A monocyte-leptin-angiogenesis pathway critical for repair post-infection.
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
11
06
2021
accepted:
29
06
2022
pubmed:
11
8
2022
medline:
9
9
2022
entrez:
10
8
2022
Statut:
ppublish
Résumé
During infection, inflammatory monocytes are thought to be key for bacterial eradication, but this is hard to reconcile with the large numbers of neutrophils that are recruited for each monocyte that migrates to the afflicted tissue, and the much more robust microbicidal functions of the neutrophils. However, unlike neutrophils, monocytes have the capacity to convert to situationally specific macrophages that may have critical functions beyond infection control
Identifiants
pubmed: 35948634
doi: 10.1038/s41586-022-05044-x
pii: 10.1038/s41586-022-05044-x
doi:
Substances chimiques
Ghrelin
0
Leptin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
166-173Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
© 2022. Crown.
Références
Shi, C. & Pamer, E. G. Monocyte recruitment during infection and inflammation. Nat. Rev. Immunol. 11, 762–774 (2011).
doi: 10.1038/nri3070
Guilliams, M., Mildner, A. & Yona, S. Developmental and functional heterogeneity of monocytes. Immunity 49, 595–613 (2018).
doi: 10.1016/j.immuni.2018.10.005
Dixit, V. D. et al. Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J. Clin. Invest. 114, 57–66 (2004).
doi: 10.1172/JCI200421134
Tsou, C. L. et al. Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites. J. Clin. Invest. 117, 902–909 (2007).
doi: 10.1172/JCI29919
Cho, J. S. et al. Neutrophil-derived IL-1β is sufficient for abscess formation in immunity against Staphylococcus aureus in mice. PLoS Pathog. 8, e1003047 (2012).
doi: 10.1371/journal.ppat.1003047
Feuerstein, R., Seidl, M., Prinz, M. & Henneke, P. MyD88 in macrophages is critical for abscess resolution in staphylococcal skin infection. J. Immunol. 194, 2735–2745 (2015).
doi: 10.4049/jimmunol.1402566
Brandt, S. L. et al. Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice. PLoS Pathog. 14, e1007244 (2018).
doi: 10.1371/journal.ppat.1007244
Thammavongsa, V., Missiakas, D. M. & Schneewind, O. Staphylococcus aureus degrades neutrophil extracellular traps to promote immune cell death. Science 342, 863–866 (2013).
doi: 10.1126/science.1242255
Willenborg, S. et al. CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 120, 613–625 (2012).
doi: 10.1182/blood-2012-01-403386
Costerton, J. W., Stewart, P. S. & Greenberg, E. P. Bacterial biofilms: a common cause of persistent infections. Science 284, 1318–1322 (1999).
doi: 10.1126/science.284.5418.1318
Mack, M. et al. Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J Immunol 166, 4697–4704 (2001).
doi: 10.4049/jimmunol.166.7.4697
Croxford, A. L. et al. The cytokine GM-CSF drives the inflammatory signature of CCR2
doi: 10.1016/j.immuni.2015.08.010
Carneiro, M. B. et al. Th1-Th2 cross-regulation controls early Leishmania infection in the skin by modulating the size of the permissive monocytic host cell reservoir. Cell Host Microbe 27, 752–768.e757 (2020).
doi: 10.1016/j.chom.2020.03.011
Tamoutounour, S. et al. Origins and functional specialization of macrophages and of conventional and monocyte-derived dendritic cells in mouse skin. Immunity 39, 925–938 (2013).
doi: 10.1016/j.immuni.2013.10.004
Baranska, A. et al. Unveiling skin macrophage dynamics explains both tattoo persistence and strenuous removal. J. Exp. Med. 215, 1115–1133 (2018).
doi: 10.1084/jem.20171608
Sierra-Honigmann, M. R. O. et al. Biological Action of Leptin as an Angiogenic Factor. Science 281, 1683–1686 (1998).
doi: 10.1126/science.281.5383.1683
Bouloumié, A., Drexler, H. C., Lafontan, M. & Busse, R. Leptin, the product of Ob gene, promotes angiogenesis. Circ. Res. 83, 1059–1066 (1998).
doi: 10.1161/01.RES.83.10.1059
Abbasi, S. et al. Distinct regulatory programs control the latent regenerative potential of dermal fibroblasts during wound healing. Cell Stem Cell 27, 396–412 e396 (2020).
doi: 10.1016/j.stem.2020.07.008
Klok, M. D., Jakobsdottir, S. & Drent, M. L. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes. Rev. 8, 21–34 (2007).
doi: 10.1111/j.1467-789X.2006.00270.x
Shook, B. A. et al. Dermal adipocyte lipolysis and myofibroblast conversion are required for efficient skin repair. Cell Stem Cell 26, 880–895 e886 (2020).
doi: 10.1016/j.stem.2020.03.013
Zhang, L. J. et al. Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science 347, 67–71 (2015).
doi: 10.1126/science.1260972
Dokoshi, T. et al. Hyaluronidase inhibits reactive adipogenesis and inflammation of colon and skin. JCI Insight 3, e123072 (2018).
doi: 10.1172/jci.insight.123072
Seim, I., Crisp, G., Shah, E. T., Jeffery, P. L. & Chopin, L. K. Abundant ghrelin gene expression by monocytes: putative implications for fat accumulation and obesity. Obes. Med. https://doi.org/10.1016/j.obmed.2016.12.001 (2017).
Frank, S., Stallmeyer, B., Kämpfer, H., Kolb, N. & Pfeilschifter, J. Leptin enhances wound re-epithelialization and constitutes a direct function of leptin in skin repair. J. Clin. Invest. 106, 501–509 (2000).
doi: 10.1172/JCI9148
Wynn, T. A. & Vannella, K. M. Macrophages in tissue repair, regeneration, and fibrosis. Immunity 44, 450–462 (2016).
doi: 10.1016/j.immuni.2016.02.015
Gonzalez-Perez, R. R., Lanier, V. & Newman, G. Leptin’s pro-angiogenic signature in breast cancer. Cancers 5, 1140–1162 (2013).
doi: 10.3390/cancers5031140
Dal-Secco, D. et al. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2
doi: 10.1084/jem.20141539
Baba, T. et al. Genome and virulence determinants of high virulence community-acquired MRSA. Lancet 359, 1819–1827 (2002).
doi: 10.1016/S0140-6736(02)08713-5
Wang, R. et al. Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA. Nat. Med. 13, 1510–1514 (2007).
doi: 10.1038/nm1656
Pang, Y. Y. et al. agr-Dependent interactions of Staphylococcus aureus USA300 with human polymorphonuclear neutrophils. J. Innate Immun. 2, 546–559 (2010).
doi: 10.1159/000319855
Harding, M. & Kubes, P. Innate immunity in the vasculature: Interactions with pathogenic bacteria. Curr. Opin. Microbiol. 15, 85–91 (2012).
doi: 10.1016/j.mib.2011.11.010
McDonald, B. et al. Intravascular danger signals guide neutrophils to sites of sterile inflammation. Science 330, 362–366 (2010).
doi: 10.1126/science.1195491
Yipp, B. G. et al. Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo. Nat. Med. 18, 1386–1393 (2012).
doi: 10.1038/nm.2847
Zwick, R. K. et al. Adipocyte hypertrophy and lipid dynamics underlie mammary gland remodeling after lactation. Nat. Commun. 9, 3592 (2018).
doi: 10.1038/s41467-018-05911-0
Stuart, T. et al. Comprehensive integration of single-cell data. Cell 177, 1888–1902.e1821 (2019).
doi: 10.1016/j.cell.2019.05.031