Spatial multi-omic map of human myocardial infarction.

Atrial Remodeling / genetics Case-Control Studies Chromatin / genetics Chromatin Assembly and Disassembly Epigenome Gene Expression Profiling Humans Myocardial Infarction / genetics Myocardium / metabolism Myocytes, Cardiac / metabolism Single-Cell Analysis Time Factors Ventricular Remodeling / genetics

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
08 2022
Historique:
received: 30 11 2020
accepted: 29 06 2022
pubmed: 11 8 2022
medline: 27 8 2022
entrez: 10 8 2022
Statut: ppublish

Résumé

Myocardial infarction is a leading cause of death worldwide

Identifiants

DOI: 10.1038/s41586-022-05060-x PMID: 35948637 PMC: PMC9364862
pubmed: 35948637
doi: 10.1038/s41586-022-05060-x
pii: 10.1038/s41586-022-05060-x
pmc: PMC9364862
doi:

Substances chimiques

Chromatin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

766-777

Subventions

Organisme : NHLBI NIH HHS
ID : R35 HL161185
Pays : United States
Organisme : European Research Council
ID : ERC-STG 677448
Pays : International
Organisme : European Research Council
ID : ERC-COG 101043403
Pays : International
Organisme : European Research Council
ID : ERC-STG 101040726
Pays : International

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Christoph Kuppe (C)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Division of Nephrology and Clinical Immunology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
ORCID: 0000-0003-4597-9833

Ricardo O Ramirez Flores (RO)

Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.
Informatics for Life, Heidelberg, Germany.
ORCID: 0000-0003-0087-371X

Zhijian Li (Z)

Institute for Computational Genomics, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany.
ORCID: 0000-0002-1523-1333

Sikander Hayat (S)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.

Rebecca T Levinson (RT)

Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.
Informatics for Life, Heidelberg, Germany.
Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg, Germany.

Xian Liao (X)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.

Monica T Hannani (MT)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.
ORCID: 0000-0002-4123-6832

Jovan Tanevski (J)

Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.
Department of Knowledge Technologies, Jožef Stefan Institute, Ljubljana, Slovenia.
ORCID: 0000-0001-7177-1003

Florian Wünnemann (F)

Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.

James S Nagai (JS)

Institute for Computational Genomics, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany.

Maurice Halder (M)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
ORCID: 0000-0003-2386-9684

David Schumacher (D)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
ORCID: 0000-0002-2308-6543

Sylvia Menzel (S)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.

Gideon Schäfer (G)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.

Konrad Hoeft (K)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
ORCID: 0000-0002-0265-0061

Mingbo Cheng (M)

Institute for Computational Genomics, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany.

Susanne Ziegler (S)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.

Xiaoting Zhang (X)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.

Fabian Peisker (F)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
ORCID: 0000-0003-0123-8179

Nadine Kaesler (N)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Division of Nephrology and Clinical Immunology, RWTH Aachen University, Medical Faculty, Aachen, Germany.

Turgay Saritas (T)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Division of Nephrology and Clinical Immunology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
ORCID: 0000-0002-6691-9218

Yaoxian Xu (Y)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.

Astrid Kassner (A)

Erich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany.

Jan Gummert (J)

Heart and Diabetes Center, North Rhine-Westphalia, Bad Oeynhausen, Germany.

Michiel Morshuis (M)

Heart and Diabetes Center, North Rhine-Westphalia, Bad Oeynhausen, Germany.

Junedh Amrute (J)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
ORCID: 0000-0002-6851-0168

Rogier J A Veltrop (RJA)

Institute for Molecular Cardiovascular Research IMCAR, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
ORCID: 0000-0002-1386-820X

Peter Boor (P)

Division of Nephrology and Clinical Immunology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Department of Pathology, RWTH Aachen University, Aachen, Germany.
ORCID: 0000-0001-9921-4284

Karin Klingel (K)

Cardiopathology, Institute for Pathology and Neuropathology, University Hospital Tübingen, Tübingen, Germany.

Linda W Van Laake (LW)

Department of Cardiology, Regenerative Medicine Center and Circulatory Health Lab, University Medical Center Utrecht, Utrecht, The Netherlands.

Aryan Vink (A)

Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
ORCID: 0000-0002-9371-8788

Remco M Hoogenboezem (RM)

Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.

Eric M J Bindels (EMJ)

Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
ORCID: 0000-0001-9502-669X

Leon Schurgers (L)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands.
ORCID: 0000-0001-7867-6957

Susanne Sattler (S)

National Heart and Lung Institute, Imperial College London, London, UK.
ORCID: 0000-0001-9932-4109

Denis Schapiro (D)

Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany.
Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
ORCID: 0000-0002-9391-5722

Rebekka K Schneider (RK)

Institute of Cell and Tumor Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Oncode Institute, Erasmus Medical Center, Rotterdam, The Netherlands.

Kory Lavine (K)

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
ORCID: 0000-0003-1948-9945

Hendrik Milting (H)

Erich and Hanna Klessmann Institute for Cardiovascular Research and Development, Clinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center NRW, Bad Oeynhausen, Germany.

Ivan G Costa (IG)

Institute for Computational Genomics, RWTH Aachen University, Medical Faculty, Aachen, Germany.
Joint Research Center for Computational Biomedicine, RWTH Aachen University Hospital, Aachen, Germany.
ORCID: 0000-0003-2890-8697

Julio Saez-Rodriguez (J)

Institute for Computational Biomedicine, Heidelberg University, Faculty of Medicine, Heidelberg University Hospital, Bioquant, Heidelberg, Germany. pub.saez@uni-heidelberg.de.
Informatics for Life, Heidelberg, Germany. pub.saez@uni-heidelberg.de.
ORCID: 0000-0002-8552-8976

Rafael Kramann (R)

Institute of Experimental Medicine and Systems Biology, RWTH Aachen University, Medical Faculty, Aachen, Germany. rkramann@gmx.net.
Division of Nephrology and Clinical Immunology, RWTH Aachen University, Medical Faculty, Aachen, Germany. rkramann@gmx.net.
Department of Internal Medicine, Nephrology and Transplantation, Erasmus Medical Center, Rotterdam, The Netherlands. rkramann@gmx.net.
ORCID: 0000-0003-4048-6351

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction auriculaire › Remodelage auriculaire › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Assemblage et désassemblage de la chromatine › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Épigénome › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Phénomènes physiques › Temps › Facteurs temps › Spatial multi-omic map of human myocardial infarction.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction ventriculaire › Remodelage ventriculaire › Spatial multi-omic map of human myocardial infarction.